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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DOHH All Species: 63.94
Human Site: Y176 Identified Species: 93.78
UniProt: Q9BU89 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BU89 NP_001138637.1 302 32904 Y176 S R P L F E R Y R A M F A L R
Chimpanzee Pan troglodytes XP_512268 302 32823 Y176 S R P L F E R Y R A M F A L R
Rhesus Macaque Macaca mulatta XP_001100385 302 32835 Y176 S R P L F E R Y R A M F A L R
Dog Lupus familis XP_542178 303 33106 Y178 A R P L F D R Y R A M F A L R
Cat Felis silvestris
Mouse Mus musculus Q99LN9 302 32887 Y177 A R P L F E R Y R A M F A L R
Rat Rattus norvegicus Q5PPJ4 302 33058 Y177 A Q P L F E R Y R A M F A L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511251 308 33581 Y176 S Q S L F D R Y Q A M F A L R
Chicken Gallus gallus Q5ZIP3 299 32857 Y176 S R P L F D R Y R A M F A L R
Frog Xenopus laevis Q66KT3 303 33366 Y178 T C P L F H R Y R A M F A L R
Zebra Danio Brachydanio rerio Q7ZUX6 305 33900 Y180 T L P L F D R Y R A M F A L R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V9U4 302 33546 Y177 Q Q S L F D R Y R A M F S L R
Honey Bee Apis mellifera XP_394239 303 34154 Y180 N I S L F E R Y R A M F S L R
Nematode Worm Caenorhab. elegans Q17949 298 33221 Y180 S L P L F D R Y R A M F S L R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94JW0 314 34074 Y190 T K G M Y E R Y A A L F A L R
Baker's Yeast Sacchar. cerevisiae P47120 325 36146 Y206 K Q P L F Q R Y R A M F R L R
Red Bread Mold Neurospora crassa Q7S891 324 35309 Y191 S L P L F K R Y R A M F A L R
Conservation
Percent
Protein Identity: 100 97.3 97.6 87.4 N.A. 84.7 83.1 N.A. 77.2 74.5 68.9 65.9 N.A. 58.6 58.4 56.2 N.A.
Protein Similarity: 100 98 98.6 94.7 N.A. 92.3 90.4 N.A. 86.3 83.4 79.8 77.6 N.A. 73.5 72.6 70.5 N.A.
P-Site Identity: 100 100 100 86.6 N.A. 93.3 86.6 N.A. 73.3 93.3 80 80 N.A. 66.6 73.3 80 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 100 86.6 93.3 N.A. 86.6 86.6 93.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 47.4 46.4 45.3
Protein Similarity: N.A. N.A. N.A. 61.4 59 60.1
P-Site Identity: N.A. N.A. N.A. 53.3 73.3 86.6
P-Site Similarity: N.A. N.A. N.A. 86.6 86.6 93.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 0 0 0 0 0 0 0 7 100 0 0 75 0 0 % A
% Cys: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 38 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 44 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 94 0 0 0 0 0 0 100 0 0 0 % F
% Gly: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 7 7 0 0 0 7 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 19 0 94 0 0 0 0 0 0 7 0 0 100 0 % L
% Met: 0 0 0 7 0 0 0 0 0 0 94 0 0 0 0 % M
% Asn: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 75 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 7 25 0 0 0 7 0 0 7 0 0 0 0 0 0 % Q
% Arg: 0 38 0 0 0 0 100 0 88 0 0 0 7 0 100 % R
% Ser: 44 0 19 0 0 0 0 0 0 0 0 0 19 0 0 % S
% Thr: 19 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 0 100 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _