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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MECR All Species: 11.21
Human Site: S33 Identified Species: 24.67
UniProt: Q9BV79 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BV79 NP_001019903.1 373 40428 S33 C H G P A A S S Y S A S A E P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001113746 373 40454 S33 C H G P A A S S Y S A S A E P
Dog Lupus familis XP_535334 367 39355 S33 P C S A P A E S S R V R A L I
Cat Felis silvestris
Mouse Mus musculus Q9DCS3 373 40324 S33 R H G R T T S S Y S A L S E P
Rat Rattus norvegicus Q9Z311 373 40308 S33 R Q G R T T S S Y S A F S E P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6GQN8 377 41060 N35 H G A V L N K N Y S S V S A V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V6U9 357 39093 E33 L K Y T Q H G E P Q E V L Q L
Honey Bee Apis mellifera XP_395130 342 38152 E33 T Q P I N Q P E N N E V S V K
Nematode Worm Caenorhab. elegans O45903 344 38177 Q33 R N P P E A I Q L K T V T I A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8LCU7 375 40805 K35 E T P T L C I K S F S T I M S
Baker's Yeast Sacchar. cerevisiae P38071 380 42048 V36 E V E D C T K V L S V K N Y T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98.1 85.7 N.A. 82 81.7 N.A. N.A. N.A. N.A. 58.8 N.A. 44.7 41.2 41.5 N.A.
Protein Similarity: 100 N.A. 98.6 90.3 N.A. 89.5 88.7 N.A. N.A. N.A. N.A. 75 N.A. 61.6 59.2 57 N.A.
P-Site Identity: 100 N.A. 100 20 N.A. 60 53.3 N.A. N.A. N.A. N.A. 13.3 N.A. 0 0 13.3 N.A.
P-Site Similarity: 100 N.A. 100 20 N.A. 66.6 60 N.A. N.A. N.A. N.A. 33.3 N.A. 6.6 13.3 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 42.4 32.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 51.3 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 10 19 37 0 0 0 0 37 0 28 10 10 % A
% Cys: 19 10 0 0 10 10 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 19 0 10 0 10 0 10 19 0 0 19 0 0 37 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 10 0 10 0 0 0 % F
% Gly: 0 10 37 0 0 0 10 0 0 0 0 0 0 0 0 % G
% His: 10 28 0 0 0 10 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 10 0 0 19 0 0 0 0 0 10 10 10 % I
% Lys: 0 10 0 0 0 0 19 10 0 10 0 10 0 0 10 % K
% Leu: 10 0 0 0 19 0 0 0 19 0 0 10 10 10 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 0 10 0 0 10 10 0 10 10 10 0 0 10 0 0 % N
% Pro: 10 0 28 28 10 0 10 0 10 0 0 0 0 0 37 % P
% Gln: 0 19 0 0 10 10 0 10 0 10 0 0 0 10 0 % Q
% Arg: 28 0 0 19 0 0 0 0 0 10 0 10 0 0 0 % R
% Ser: 0 0 10 0 0 0 37 46 19 55 19 19 37 0 10 % S
% Thr: 10 10 0 19 19 28 0 0 0 0 10 10 10 0 10 % T
% Val: 0 10 0 10 0 0 0 10 0 0 19 37 0 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 46 0 0 0 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _