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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MECR All Species: 23.64
Human Site: T281 Identified Species: 52
UniProt: Q9BV79 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BV79 NP_001019903.1 373 40428 T281 R Q L A R G G T M V T Y G G M
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001113746 373 40454 T281 R Q L A R G G T M V T Y G G M
Dog Lupus familis XP_535334 367 39355 T274 R H L A P G G T M V T Y G G M
Cat Felis silvestris
Mouse Mus musculus Q9DCS3 373 40324 T281 R H L A P G G T M V T Y G G M
Rat Rattus norvegicus Q9Z311 373 40308 T281 R H L A P G G T M V T Y G G M
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6GQN8 377 41060 S283 R H L Q S G G S L V T Y G G M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V6U9 357 39093 V260 R H L D N G G V L V T Y G G M
Honey Bee Apis mellifera XP_395130 342 38152 G249 G G I M I T Y G G M S R E P L
Nematode Worm Caenorhab. elegans O45903 344 38177 C251 S L L D H G G C M V T Y G G M
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8LCU7 375 40805 T283 K Y L R E G G T M V T Y G G M
Baker's Yeast Sacchar. cerevisiae P38071 380 42048 L279 R K L E N N A L M L T Y G G M
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98.1 85.7 N.A. 82 81.7 N.A. N.A. N.A. N.A. 58.8 N.A. 44.7 41.2 41.5 N.A.
Protein Similarity: 100 N.A. 98.6 90.3 N.A. 89.5 88.7 N.A. N.A. N.A. N.A. 75 N.A. 61.6 59.2 57 N.A.
P-Site Identity: 100 N.A. 100 86.6 N.A. 86.6 86.6 N.A. N.A. N.A. N.A. 66.6 N.A. 66.6 0 66.6 N.A.
P-Site Similarity: 100 N.A. 100 86.6 N.A. 86.6 86.6 N.A. N.A. N.A. N.A. 80 N.A. 73.3 26.6 66.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 42.4 32.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 51.3 N.A.
P-Site Identity: N.A. N.A. N.A. 73.3 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 80 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 46 0 0 10 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 19 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 10 10 0 0 0 0 0 0 0 10 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 10 0 0 0 82 82 10 10 0 0 0 91 91 0 % G
% His: 0 46 0 0 10 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 10 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 10 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 10 91 0 0 0 0 10 19 10 0 0 0 0 10 % L
% Met: 0 0 0 10 0 0 0 0 73 10 0 0 0 0 91 % M
% Asn: 0 0 0 0 19 10 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 28 0 0 0 0 0 0 0 0 10 0 % P
% Gln: 0 19 0 10 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 73 0 0 10 19 0 0 0 0 0 0 10 0 0 0 % R
% Ser: 10 0 0 0 10 0 0 10 0 0 10 0 0 0 0 % S
% Thr: 0 0 0 0 0 10 0 55 0 0 91 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 10 0 82 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 0 0 0 0 10 0 0 0 0 91 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _