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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ACAT2 All Species: 25.15
Human Site: S123 Identified Species: 61.48
UniProt: Q9BWD1 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BWD1 NP_005882.2 397 41351 S123 A G G M E N M S K A P H L A Y
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001106967 397 41513 S123 A G G M E N M S K A P H L A H
Dog Lupus familis XP_541180 397 41084 S123 A G G M E S M S K A P H L V H
Cat Felis silvestris
Mouse Mus musculus Q8CAY6 397 41279 S123 A G G M E N M S K A P H L T H
Rat Rattus norvegicus Q5XI22 397 41090 S123 A G G M E N M S K A P H L A H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q6NU46 420 44109 M149 V A G G M E S M S N V P Y C M
Zebra Danio Brachydanio rerio Q6AZA0 420 44324 S150 A G G M E S M S Q V P Y I M A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001198891 394 40735 S120 A G G Q E S M S Q A P H A A H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8S4Y1 403 41393 N129 G G M E S M S N T P K Y L A E
Baker's Yeast Sacchar. cerevisiae P41338 398 41710 N123 G G C E S M T N A P Y Y M P A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 90.6 88.1 N.A. 87.6 87.1 N.A. N.A. N.A. 40.4 42.1 N.A. N.A. N.A. N.A. 63.2
Protein Similarity: 100 N.A. 93.1 92.6 N.A. 94.2 94.2 N.A. N.A. N.A. 60.2 60.2 N.A. N.A. N.A. N.A. 75.8
P-Site Identity: 100 N.A. 93.3 80 N.A. 86.6 93.3 N.A. N.A. N.A. 6.6 53.3 N.A. N.A. N.A. N.A. 66.6
P-Site Similarity: 100 N.A. 100 93.3 N.A. 93.3 100 N.A. N.A. N.A. 6.6 80 N.A. N.A. N.A. N.A. 86.6
Percent
Protein Identity: N.A. N.A. N.A. 46.4 42.2 N.A.
Protein Similarity: N.A. N.A. N.A. 61 60 N.A.
P-Site Identity: N.A. N.A. N.A. 20 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 70 10 0 0 0 0 0 0 10 60 0 0 10 50 20 % A
% Cys: 0 0 10 0 0 0 0 0 0 0 0 0 0 10 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 20 70 10 0 0 0 0 0 0 0 0 10 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 20 90 80 10 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 60 0 0 50 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 50 0 10 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 60 0 0 % L
% Met: 0 0 10 60 10 20 70 10 0 0 0 0 10 10 10 % M
% Asn: 0 0 0 0 0 40 0 20 0 10 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 20 70 10 0 10 0 % P
% Gln: 0 0 0 10 0 0 0 0 20 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 20 30 20 70 10 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 10 0 10 0 0 0 0 10 0 % T
% Val: 10 0 0 0 0 0 0 0 0 10 10 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 10 30 10 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _