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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TRPM6
All Species:
4.55
Human Site:
S445
Identified Species:
12.5
UniProt:
Q9BX84
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BX84
NP_060132.3
2022
231708
S445
D
A
L
E
Q
A
M
S
D
A
L
V
M
D
R
Chimpanzee
Pan troglodytes
XP_528327
2017
230942
S440
D
A
L
E
Q
A
M
S
D
A
L
V
M
D
R
Rhesus Macaque
Macaca mulatta
XP_001094459
2126
241799
L546
D
A
L
E
Q
A
M
L
D
A
L
V
M
D
R
Dog
Lupus familis
XP_541279
2031
232519
L447
G
A
L
E
Q
A
M
L
D
A
L
V
M
D
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIR4
2028
232870
L436
G
A
L
E
Q
A
M
L
D
A
L
V
M
D
R
Rat
Rattus norvegicus
Q925B3
1862
212335
M369
V
H
L
F
Q
T
M
M
E
C
M
K
K
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_425074
1869
212093
E376
L
E
C
M
K
K
K
E
L
I
T
V
F
H
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001025232
1774
201423
P281
A
R
I
G
Q
G
V
P
V
V
A
L
I
F
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A8DYE2
2023
225520
I513
L
T
W
N
R
V
D
I
A
R
S
E
I
F
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
91.5
85.3
N.A.
78.1
52.5
N.A.
N.A.
53.2
N.A.
52
N.A.
31.7
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
93
90.8
N.A.
85.3
66.6
N.A.
N.A.
67.5
N.A.
65.7
N.A.
50.5
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
86.6
N.A.
86.6
20
N.A.
N.A.
6.6
N.A.
6.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
86.6
N.A.
86.6
33.3
N.A.
N.A.
13.3
N.A.
33.3
N.A.
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
56
0
0
0
56
0
0
12
56
12
0
0
0
0
% A
% Cys:
0
0
12
0
0
0
0
0
0
12
0
0
0
0
0
% C
% Asp:
34
0
0
0
0
0
12
0
56
0
0
0
0
56
0
% D
% Glu:
0
12
0
56
0
0
0
12
12
0
0
12
0
0
23
% E
% Phe:
0
0
0
12
0
0
0
0
0
0
0
0
12
23
0
% F
% Gly:
23
0
0
12
0
12
0
0
0
0
0
0
0
0
0
% G
% His:
0
12
0
0
0
0
0
0
0
0
0
0
0
12
0
% H
% Ile:
0
0
12
0
0
0
0
12
0
12
0
0
23
0
12
% I
% Lys:
0
0
0
0
12
12
12
0
0
0
0
12
12
12
0
% K
% Leu:
23
0
67
0
0
0
0
34
12
0
56
12
0
0
0
% L
% Met:
0
0
0
12
0
0
67
12
0
0
12
0
56
0
0
% M
% Asn:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
78
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
12
0
0
12
0
0
0
0
12
0
0
0
0
56
% R
% Ser:
0
0
0
0
0
0
0
23
0
0
12
0
0
0
0
% S
% Thr:
0
12
0
0
0
12
0
0
0
0
12
0
0
0
0
% T
% Val:
12
0
0
0
0
12
12
0
12
12
0
67
0
0
12
% V
% Trp:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _