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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PAPPA2 All Species: 13.64
Human Site: Y666 Identified Species: 37.5
UniProt: Q9BXP8 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BXP8 NP_064714.2 1791 198539 Y666 P D S P K R A Y M S V K E L K
Chimpanzee Pan troglodytes XP_514020 1791 198653 Y666 P D S P K R A Y M S V K E L K
Rhesus Macaque Macaca mulatta XP_001095160 1573 175281 H501 C N H T L T G H D G G D C R H
Dog Lupus familis XP_537179 1778 195855 Y657 P D S P K R A Y M S V K E L K
Cat Felis silvestris
Mouse Mus musculus Q8R4K8 1624 181300 G552 P S F Y G I P G H T H T M I H
Rat Rattus norvegicus XP_001073420 1788 198541 Y666 P D S P K R A Y M S V K E L K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_426627 1551 171156 V479 L S H L G G V V L S P A Y Y G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_695417 1759 195473 L660 E S P Q R A Y L S V K E L K E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_795597 1601 177169 L529 H L N N S D A L N V F F V D F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 39.7 81.7 N.A. 43.6 79.4 N.A. N.A. 57.9 N.A. 48 N.A. N.A. N.A. N.A. 33.6
Protein Similarity: 100 99.7 56.3 89 N.A. 60 87.2 N.A. N.A. 68.2 N.A. 63.8 N.A. N.A. N.A. N.A. 49
P-Site Identity: 100 100 0 100 N.A. 6.6 100 N.A. N.A. 6.6 N.A. 0 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 13.3 100 N.A. 20 100 N.A. N.A. 13.3 N.A. 20 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 12 56 0 0 0 0 12 0 0 0 % A
% Cys: 12 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % C
% Asp: 0 45 0 0 0 12 0 0 12 0 0 12 0 12 0 % D
% Glu: 12 0 0 0 0 0 0 0 0 0 0 12 45 0 12 % E
% Phe: 0 0 12 0 0 0 0 0 0 0 12 12 0 0 12 % F
% Gly: 0 0 0 0 23 12 12 12 0 12 12 0 0 0 12 % G
% His: 12 0 23 0 0 0 0 12 12 0 12 0 0 0 23 % H
% Ile: 0 0 0 0 0 12 0 0 0 0 0 0 0 12 0 % I
% Lys: 0 0 0 0 45 0 0 0 0 0 12 45 0 12 45 % K
% Leu: 12 12 0 12 12 0 0 23 12 0 0 0 12 45 0 % L
% Met: 0 0 0 0 0 0 0 0 45 0 0 0 12 0 0 % M
% Asn: 0 12 12 12 0 0 0 0 12 0 0 0 0 0 0 % N
% Pro: 56 0 12 45 0 0 12 0 0 0 12 0 0 0 0 % P
% Gln: 0 0 0 12 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 12 45 0 0 0 0 0 0 0 12 0 % R
% Ser: 0 34 45 0 12 0 0 0 12 56 0 0 0 0 0 % S
% Thr: 0 0 0 12 0 12 0 0 0 12 0 12 0 0 0 % T
% Val: 0 0 0 0 0 0 12 12 0 23 45 0 12 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 12 0 0 12 45 0 0 0 0 12 12 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _