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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC8
All Species:
22.73
Human Site:
S329
Identified Species:
31.25
UniProt:
Q9BY41
Number Species:
16
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY41
NP_060956.1
377
41758
S329
I
L
G
K
T
L
S
S
E
I
P
D
H
E
F
Chimpanzee
Pan troglodytes
XP_001140380
415
46624
S367
I
L
G
K
T
L
S
S
E
I
P
D
H
E
F
Rhesus Macaque
Macaca mulatta
XP_001093861
377
41783
S329
I
L
G
K
T
L
S
S
E
I
P
D
H
E
F
Dog
Lupus familis
XP_538078
377
41675
S329
I
L
G
K
T
L
S
S
E
I
P
D
H
E
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8VH37
377
41753
S329
I
L
G
K
T
L
S
S
E
I
P
D
H
E
F
Rat
Rattus norvegicus
Q4QQW4
482
55074
N326
A
L
D
T
E
I
P
N
E
L
P
Y
N
D
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510728
773
87357
S623
I
L
G
R
T
L
S
S
E
I
P
D
H
E
F
Chicken
Gallus gallus
P56517
480
54920
N326
A
L
D
T
E
I
P
N
E
L
P
Y
N
D
Y
Frog
Xenopus laevis
O42227
480
54874
N326
A
L
D
S
E
I
P
N
E
L
P
Y
N
D
Y
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
D321
L
V
E
E
S
I
S
D
E
L
P
Y
S
E
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
N324
A
L
A
V
E
I
A
N
E
L
P
Y
N
D
Y
Honey Bee
Apis mellifera
XP_394976
461
52425
E387
V
I
E
D
S
E
A
E
E
K
V
N
P
D
E
Nematode Worm
Caenorhab. elegans
O17695
461
52119
N330
A
V
D
K
E
V
P
N
E
L
P
Y
N
D
Y
Sea Urchin
Strong. purpuratus
P56518
576
64060
N325
A
L
G
V
E
I
A
N
E
L
P
Y
N
D
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
D339
A
L
G
Q
E
P
E
D
K
M
P
V
N
E
Y
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H0W2
426
48669
N323
L
L
D
T
E
L
P
N
E
I
P
E
N
D
Y
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
K336
L
N
N
V
V
L
D
K
D
L
P
Y
N
E
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.9
99.1
97.6
N.A.
96.2
32.7
N.A.
44.2
32.5
33.3
37.3
N.A.
30.1
35.1
34.4
27.7
Protein Similarity:
100
87.7
99.7
99.1
N.A.
98.1
50.2
N.A.
47.3
50
50.6
56.3
N.A.
46.6
54
51.4
42.3
P-Site Identity:
100
100
100
100
N.A.
100
20
N.A.
93.3
20
20
26.6
N.A.
20
6.6
20
26.6
P-Site Similarity:
100
100
100
100
N.A.
100
60
N.A.
100
60
60
73.3
N.A.
66.6
46.6
66.6
73.3
Percent
Protein Identity:
N.A.
33.3
N.A.
38.5
36.4
N.A.
Protein Similarity:
N.A.
48.1
N.A.
57.2
55.4
N.A.
P-Site Identity:
N.A.
26.6
N.A.
33.3
20
N.A.
P-Site Similarity:
N.A.
60
N.A.
73.3
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
42
0
6
0
0
0
18
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
30
6
0
0
6
12
6
0
0
36
0
48
0
% D
% Glu:
0
0
12
6
48
6
6
6
89
0
0
6
0
53
6
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
36
% F
% Gly:
0
0
48
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
36
0
0
% H
% Ile:
36
6
0
0
0
36
0
0
0
42
0
0
0
0
0
% I
% Lys:
0
0
0
36
0
0
0
6
6
6
0
0
0
0
0
% K
% Leu:
18
77
0
0
0
48
0
0
0
48
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
6
0
0
0
0
0
% M
% Asn:
0
6
6
0
0
0
0
42
0
0
0
6
53
0
0
% N
% Pro:
0
0
0
0
0
6
30
0
0
0
95
0
6
0
0
% P
% Gln:
0
0
0
6
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
6
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
6
12
0
42
36
0
0
0
0
6
0
0
% S
% Thr:
0
0
0
18
36
0
0
0
0
0
0
0
0
0
0
% T
% Val:
6
12
0
18
6
6
0
0
0
0
6
6
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
48
0
0
59
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _