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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC8
All Species:
37.88
Human Site:
T349
Identified Species:
52.08
UniProt:
Q9BY41
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY41
NP_060956.1
377
41758
T349
P
D
Y
V
L
E
I
T
P
S
C
R
P
D
R
Chimpanzee
Pan troglodytes
XP_001140380
415
46624
T387
P
D
Y
V
L
E
I
T
P
S
C
R
P
D
R
Rhesus Macaque
Macaca mulatta
XP_001093861
377
41783
T349
P
D
Y
V
L
E
I
T
P
S
C
R
P
D
R
Dog
Lupus familis
XP_538078
377
41675
T349
P
D
Y
V
L
E
I
T
P
S
C
R
P
D
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8VH37
377
41753
T349
P
D
Y
V
L
E
I
T
P
S
C
R
P
D
R
Rat
Rattus norvegicus
Q4QQW4
482
55074
S346
P
D
F
K
L
H
I
S
P
S
N
M
T
N
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510728
773
87357
T643
P
D
Y
V
L
E
I
T
P
S
C
R
P
D
R
Chicken
Gallus gallus
P56517
480
54920
S346
P
D
F
K
L
H
I
S
P
S
N
M
T
N
Q
Frog
Xenopus laevis
O42227
480
54874
S346
P
D
F
K
L
H
I
S
P
S
N
M
T
N
Q
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
D341
P
D
F
T
L
H
P
D
V
S
T
R
I
E
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
S344
P
D
F
K
L
H
I
S
P
S
N
M
T
N
Q
Honey Bee
Apis mellifera
XP_394976
461
52425
H407
D
L
D
K
R
I
Q
H
E
N
E
Y
S
D
S
Nematode Worm
Caenorhab. elegans
O17695
461
52119
E350
P
N
Y
R
L
H
I
E
S
S
N
A
A
N
E
Sea Urchin
Strong. purpuratus
P56518
576
64060
S345
P
D
F
K
L
H
I
S
P
S
N
M
T
N
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
A359
P
D
Y
T
L
H
V
A
P
S
N
M
E
N
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H0W2
426
48669
P343
P
D
F
S
L
K
I
P
G
G
H
I
E
N
L
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
R356
P
D
Y
K
L
S
V
R
P
S
N
M
F
N
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.9
99.1
97.6
N.A.
96.2
32.7
N.A.
44.2
32.5
33.3
37.3
N.A.
30.1
35.1
34.4
27.7
Protein Similarity:
100
87.7
99.7
99.1
N.A.
98.1
50.2
N.A.
47.3
50
50.6
56.3
N.A.
46.6
54
51.4
42.3
P-Site Identity:
100
100
100
100
N.A.
100
40
N.A.
100
40
40
33.3
N.A.
40
6.6
33.3
40
P-Site Similarity:
100
100
100
100
N.A.
100
66.6
N.A.
100
66.6
66.6
46.6
N.A.
66.6
13.3
46.6
66.6
Percent
Protein Identity:
N.A.
33.3
N.A.
38.5
36.4
N.A.
Protein Similarity:
N.A.
48.1
N.A.
57.2
55.4
N.A.
P-Site Identity:
N.A.
40
N.A.
26.6
40
N.A.
P-Site Similarity:
N.A.
60
N.A.
46.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
6
0
0
0
6
6
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
36
0
0
0
0
% C
% Asp:
6
89
6
0
0
0
0
6
0
0
0
0
0
42
0
% D
% Glu:
0
0
0
0
0
36
0
6
6
0
6
0
12
6
6
% E
% Phe:
0
0
42
0
0
0
0
0
0
0
0
0
6
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
6
6
0
0
0
0
0
% G
% His:
0
0
0
0
0
48
0
6
0
0
6
0
0
0
0
% H
% Ile:
0
0
0
0
0
6
77
0
0
0
0
6
6
0
0
% I
% Lys:
0
0
0
42
0
6
0
0
0
0
0
0
0
0
6
% K
% Leu:
0
6
0
0
95
0
0
0
0
0
0
0
0
0
6
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
42
0
0
0
% M
% Asn:
0
6
0
0
0
0
0
0
0
6
48
0
0
53
6
% N
% Pro:
95
0
0
0
0
0
6
6
77
0
0
0
36
0
0
% P
% Gln:
0
0
0
0
0
0
6
0
0
0
0
0
0
0
30
% Q
% Arg:
0
0
0
6
6
0
0
6
0
0
0
42
0
0
36
% R
% Ser:
0
0
0
6
0
6
0
30
6
89
0
0
6
0
6
% S
% Thr:
0
0
0
12
0
0
0
36
0
0
6
0
30
0
0
% T
% Val:
0
0
0
36
0
0
12
0
6
0
0
0
0
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
53
0
0
0
0
0
0
0
0
6
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _