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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HDAC8 All Species: 21.82
Human Site: Y241 Identified Species: 30
UniProt: Q9BY41 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.19
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BY41 NP_060956.1 377 41758 Y241 G I Q D E K Y Y Q I C E S V L
Chimpanzee Pan troglodytes XP_001140380 415 46624 Y279 G I Q D E K Y Y Q I C E S V L
Rhesus Macaque Macaca mulatta XP_001093861 377 41783 Y241 G I Q D E K Y Y Q I F E S V L
Dog Lupus familis XP_538078 377 41675 Y241 G I Q D E K Y Y H I C E S V L
Cat Felis silvestris
Mouse Mus musculus Q8VH37 377 41753 Y241 G I Q D E K Y Y H I C E S V L
Rat Rattus norvegicus Q4QQW4 482 55074 E238 G I D D E S Y E A I F K P V M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510728 773 87357 Y535 G I Q D E K Y Y Q I C E S V L
Chicken Gallus gallus P56517 480 54920 E238 G I D D E S Y E A I F K P V I
Frog Xenopus laevis O42227 480 54874 E238 G I D D E S Y E A I F K P V M
Zebra Danio Brachydanio rerio Q803C3 428 48962 R233 G I D D Q S Y R Q L F Q P V I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q94517 521 58312 E236 G M D D D A Y E S I F V P I I
Honey Bee Apis mellifera XP_394976 461 52425 V278 H G K C V E F V K K Y N L P F
Nematode Worm Caenorhab. elegans O17695 461 52119 Q242 G I T D V S Y Q S I F K P I M
Sea Urchin Strong. purpuratus P56518 576 64060 D237 G I D D E S Y D K I F K P I M
Poplar Tree Populus trichocarpa
Maize Zea mays P56521 513 57528 Q251 G I D D E S Y Q S L F K P I M
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8H0W2 426 48669 N235 G I D D S S F N R L F R T I I
Baker's Yeast Sacchar. cerevisiae P32561 433 48886 R248 G I D D A T Y R S V F E P V I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86.9 99.1 97.6 N.A. 96.2 32.7 N.A. 44.2 32.5 33.3 37.3 N.A. 30.1 35.1 34.4 27.7
Protein Similarity: 100 87.7 99.7 99.1 N.A. 98.1 50.2 N.A. 47.3 50 50.6 56.3 N.A. 46.6 54 51.4 42.3
P-Site Identity: 100 100 93.3 93.3 N.A. 93.3 46.6 N.A. 100 46.6 46.6 40 N.A. 26.6 0 33.3 40
P-Site Similarity: 100 100 93.3 93.3 N.A. 93.3 60 N.A. 100 60 60 66.6 N.A. 53.3 26.6 53.3 66.6
Percent
Protein Identity: N.A. 33.3 N.A. 38.5 36.4 N.A.
Protein Similarity: N.A. 48.1 N.A. 57.2 55.4 N.A.
P-Site Identity: N.A. 33.3 N.A. 20 40 N.A.
P-Site Similarity: N.A. 60 N.A. 60 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 6 6 0 0 18 0 0 0 0 0 0 % A
% Cys: 0 0 0 6 0 0 0 0 0 0 30 0 0 0 0 % C
% Asp: 0 0 53 95 6 0 0 6 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 65 6 0 24 0 0 0 42 0 0 0 % E
% Phe: 0 0 0 0 0 0 12 0 0 0 65 0 0 0 6 % F
% Gly: 95 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 6 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % H
% Ile: 0 89 0 0 0 0 0 0 0 71 0 0 0 30 30 % I
% Lys: 0 0 6 0 0 36 0 0 12 6 0 36 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 18 0 0 6 0 36 % L
% Met: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 30 % M
% Asn: 0 0 0 0 0 0 0 6 0 0 0 6 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 53 6 0 % P
% Gln: 0 0 36 0 6 0 0 12 30 0 0 6 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 12 6 0 0 6 0 0 0 % R
% Ser: 0 0 0 0 6 48 0 0 24 0 0 0 36 0 0 % S
% Thr: 0 0 6 0 0 6 0 0 0 0 0 0 6 0 0 % T
% Val: 0 0 0 0 12 0 0 6 0 6 0 6 0 65 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 89 36 0 0 6 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _