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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HDAC8 All Species: 26.06
Human Site: Y368 Identified Species: 35.83
UniProt: Q9BY41 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BY41 NP_060956.1 377 41758 Y368 R I Q Q I L N Y I K G N L K H
Chimpanzee Pan troglodytes XP_001140380 415 46624 Y406 R I Q Q I L N Y I K G N L K H
Rhesus Macaque Macaca mulatta XP_001093861 377 41783 Y368 R I Q Q I L N Y I K G N L K H
Dog Lupus familis XP_538078 377 41675 Y368 R V Q Q I L N Y I K G N L K H
Cat Felis silvestris
Mouse Mus musculus Q8VH37 377 41753 Y368 R I Q Q I L N Y I K G N L K H
Rat Rattus norvegicus Q4QQW4 482 55074 R365 Y L E K I K Q R L F E N L R M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510728 773 87357 S662 K V Q Q I L N S I R G E Q H R
Chicken Gallus gallus P56517 480 54920 R365 Y L E K I K Q R L F E N L R M
Frog Xenopus laevis O42227 480 54874 R365 Y L E K I K Q R L F E N L R M
Zebra Danio Brachydanio rerio Q803C3 428 48962 T361 Y L E Q I R Q T V F E N L K M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q94517 521 58312 R363 Y L E K I K N R L F E N L R M
Honey Bee Apis mellifera XP_394976 461 52425 G443 R L E K G Q E G I E S D L K K
Nematode Worm Caenorhab. elegans O17695 461 52119 D369 M L A K L Q T D V I A N L E Q
Sea Urchin Strong. purpuratus P56518 576 64060 R364 Y L D K I K T R L Y E N M R M
Poplar Tree Populus trichocarpa
Maize Zea mays P56521 513 57528 A385 K L S K L R H A P S V H F Q E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8H0W2 426 48669 Y416 Q I Q R D D E Y F D G D N D N
Baker's Yeast Sacchar. cerevisiae P32561 433 48886 N375 Y L D K V M T N I F A N L E N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86.9 99.1 97.6 N.A. 96.2 32.7 N.A. 44.2 32.5 33.3 37.3 N.A. 30.1 35.1 34.4 27.7
Protein Similarity: 100 87.7 99.7 99.1 N.A. 98.1 50.2 N.A. 47.3 50 50.6 56.3 N.A. 46.6 54 51.4 42.3
P-Site Identity: 100 100 100 93.3 N.A. 100 20 N.A. 46.6 20 20 33.3 N.A. 26.6 26.6 13.3 13.3
P-Site Similarity: 100 100 100 100 N.A. 100 53.3 N.A. 66.6 53.3 53.3 53.3 N.A. 60 60 46.6 46.6
Percent
Protein Identity: N.A. 33.3 N.A. 38.5 36.4 N.A.
Protein Similarity: N.A. 48.1 N.A. 57.2 55.4 N.A.
P-Site Identity: N.A. 0 N.A. 26.6 20 N.A.
P-Site Similarity: N.A. 46.6 N.A. 53.3 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 6 0 0 0 0 6 0 0 12 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 12 0 6 6 0 6 0 6 0 12 0 6 0 % D
% Glu: 0 0 36 0 0 0 12 0 0 6 36 6 0 12 6 % E
% Phe: 0 0 0 0 0 0 0 0 6 36 0 0 6 0 0 % F
% Gly: 0 0 0 0 6 0 0 6 0 0 42 0 0 0 0 % G
% His: 0 0 0 0 0 0 6 0 0 0 0 6 0 6 30 % H
% Ile: 0 30 0 0 71 0 0 0 48 6 0 0 0 0 0 % I
% Lys: 12 0 0 53 0 30 0 0 0 30 0 0 0 42 6 % K
% Leu: 0 59 0 0 12 36 0 0 30 0 0 0 77 0 0 % L
% Met: 6 0 0 0 0 6 0 0 0 0 0 0 6 0 36 % M
% Asn: 0 0 0 0 0 0 42 6 0 0 0 77 6 0 12 % N
% Pro: 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 % P
% Gln: 6 0 42 42 0 12 24 0 0 0 0 0 6 6 6 % Q
% Arg: 36 0 0 6 0 12 0 30 0 6 0 0 0 30 6 % R
% Ser: 0 0 6 0 0 0 0 6 0 6 6 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 18 6 0 0 0 0 0 0 0 % T
% Val: 0 12 0 0 6 0 0 0 12 0 6 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 42 0 0 0 0 0 0 36 0 6 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _