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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC8
All Species:
30.3
Human Site:
Y75
Identified Species:
41.67
UniProt:
Q9BY41
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY41
NP_060956.1
377
41758
Y75
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
Chimpanzee
Pan troglodytes
XP_001140380
415
46624
Y113
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
Rhesus Macaque
Macaca mulatta
XP_001093861
377
41783
Y75
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
Dog
Lupus familis
XP_538078
377
41675
Y75
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8VH37
377
41753
Y75
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
Rat
Rattus norvegicus
Q4QQW4
482
55074
I73
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510728
773
87357
Y369
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
Chicken
Gallus gallus
P56517
480
54920
I73
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
R
Frog
Xenopus laevis
O42227
480
54874
I73
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
R
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
V73
Y
I
D
F
L
Q
K
V
S
P
N
N
M
Q
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
F73
H
S
D
E
Y
V
R
F
L
R
S
I
R
P
D
Honey Bee
Apis mellifera
XP_394976
461
52425
D89
Q
R
F
N
V
G
E
D
C
P
V
F
D
G
L
Nematode Worm
Caenorhab. elegans
O17695
461
52119
Y76
T
R
F
H
S
D
E
Y
M
T
F
L
K
S
A
Sea Urchin
Strong. purpuratus
P56518
576
64060
F74
H
S
D
D
Y
V
K
F
L
R
T
I
R
P
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
Y86
C
R
F
H
A
E
E
Y
I
N
F
L
R
S
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H0W2
426
48669
R74
D
Y
V
E
F
L
Q
R
I
N
P
E
N
Q
N
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
Y82
C
Q
F
H
T
D
E
Y
I
D
F
L
S
R
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.9
99.1
97.6
N.A.
96.2
32.7
N.A.
44.2
32.5
33.3
37.3
N.A.
30.1
35.1
34.4
27.7
Protein Similarity:
100
87.7
99.7
99.1
N.A.
98.1
50.2
N.A.
47.3
50
50.6
56.3
N.A.
46.6
54
51.4
42.3
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
100
6.6
6.6
0
N.A.
6.6
6.6
33.3
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
6.6
N.A.
100
6.6
6.6
13.3
N.A.
40
20
53.3
40
Percent
Protein Identity:
N.A.
33.3
N.A.
38.5
36.4
N.A.
Protein Similarity:
N.A.
48.1
N.A.
57.2
55.4
N.A.
P-Site Identity:
N.A.
33.3
N.A.
0
46.6
N.A.
P-Site Similarity:
N.A.
53.3
N.A.
13.3
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
36
0
0
0
6
0
36
0
0
0
0
0
0
0
6
% A
% Cys:
12
0
0
0
0
0
0
0
6
0
0
0
0
0
0
% C
% Asp:
6
0
18
6
18
65
0
6
0
6
0
0
6
0
12
% D
% Glu:
0
0
0
12
0
6
24
0
0
0
0
6
0
0
0
% E
% Phe:
0
0
59
6
6
0
0
12
0
18
18
6
0
0
0
% F
% Gly:
0
0
0
0
0
6
0
0
0
0
0
0
0
6
6
% G
% His:
12
0
18
53
0
0
0
0
0
0
36
0
0
0
0
% H
% Ile:
0
6
0
0
0
0
0
18
18
0
0
12
0
18
0
% I
% Lys:
18
0
0
0
0
0
12
0
18
0
0
0
6
36
0
% K
% Leu:
0
0
0
0
6
6
0
0
48
0
18
53
0
0
6
% L
% Met:
0
0
0
0
0
0
0
0
6
0
0
0
6
0
0
% M
% Asn:
0
0
0
6
0
0
0
0
0
12
6
6
6
0
6
% N
% Pro:
0
0
0
0
0
0
0
0
0
12
6
0
0
12
0
% P
% Gln:
6
6
0
0
0
6
6
0
0
36
0
0
36
12
0
% Q
% Arg:
0
18
0
0
0
0
6
6
0
12
0
18
18
6
18
% R
% Ser:
0
12
0
18
6
0
0
0
6
0
6
0
24
12
0
% S
% Thr:
6
36
0
0
42
0
0
0
0
6
6
0
0
0
0
% T
% Val:
0
0
6
0
6
12
0
6
0
0
6
0
0
0
48
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
6
24
0
0
12
0
18
53
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _