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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2A All Species: 24.24
Human Site: S176 Identified Species: 41.03
UniProt: Q9BY44 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BY44 NP_114414.2 585 64990 S176 K I N D F V L S P G P Q P Y K
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001108004 580 64436 S171 K I N D F V L S P G P Q P Y K
Dog Lupus familis XP_534306 585 65159 S176 K I N D F V L S P G P Q P Y K
Cat Felis silvestris
Mouse Mus musculus Q8BJW6 581 64385 S176 K V N D F N L S P G T Q P Y K
Rat Rattus norvegicus NP_001102809 541 60196 G168 Y Q Y P N F A G P Q A A L A N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507598 493 54394 H120 Y P N F G G P H A A L A N K S
Chicken Gallus gallus Q5ZKC1 586 64485 S176 K V N D F V L S P G A Q P T K
Frog Xenopus laevis Q7ZY11 582 64798 S178 K V S D F E L S P G E Q P C K
Zebra Danio Brachydanio rerio Q4QRJ7 580 64206 S175 K V S E F A L S P G S Q P S K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VNX8 638 70052 L192 S R G G M L S L G P G N C P P
Honey Bee Apis mellifera XP_625143 577 65273 I175 A K V A K F S I S P S N T P Y
Nematode Worm Caenorhab. elegans Q19052 570 64001 A179 E K G A T N F A L S P G P A P
Sea Urchin Strong. purpuratus XP_001186352 299 33040
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53235 642 71286 H194 Y L I S P A E H P T I C T F T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 97.4 96 N.A. 92.8 82.5 N.A. 74.5 84.4 74.8 69.5 N.A. 39 43.9 35.7 29.2
Protein Similarity: 100 N.A. 98.2 98.2 N.A. 95.5 87 N.A. 79.4 91.6 86.5 81.5 N.A. 56.5 61.3 54.8 40
P-Site Identity: 100 N.A. 100 100 N.A. 80 6.6 N.A. 6.6 80 66.6 60 N.A. 0 0 13.3 0
P-Site Similarity: 100 N.A. 100 100 N.A. 86.6 6.6 N.A. 6.6 86.6 80 80 N.A. 6.6 0 26.6 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 15 0 15 8 8 8 8 15 15 0 15 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 8 8 8 0 % C
% Asp: 0 0 0 43 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 8 0 0 8 0 8 8 0 0 0 8 0 0 0 0 % E
% Phe: 0 0 0 8 50 15 8 0 0 0 0 0 0 8 0 % F
% Gly: 0 0 15 8 8 8 0 8 8 50 8 8 0 0 0 % G
% His: 0 0 0 0 0 0 0 15 0 0 0 0 0 0 0 % H
% Ile: 0 22 8 0 0 0 0 8 0 0 8 0 0 0 0 % I
% Lys: 50 15 0 0 8 0 0 0 0 0 0 0 0 8 50 % K
% Leu: 0 8 0 0 0 8 50 8 8 0 8 0 8 0 0 % L
% Met: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 43 0 8 15 0 0 0 0 0 15 8 0 8 % N
% Pro: 0 8 0 8 8 0 8 0 65 15 29 0 58 15 15 % P
% Gln: 0 8 0 0 0 0 0 0 0 8 0 50 0 0 0 % Q
% Arg: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 8 0 15 8 0 0 15 50 8 8 15 0 0 8 8 % S
% Thr: 0 0 0 0 8 0 0 0 0 8 8 0 15 8 8 % T
% Val: 0 29 8 0 0 29 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 22 0 8 0 0 0 0 0 0 0 0 0 0 29 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _