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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2A
All Species:
9.7
Human Site:
S474
Identified Species:
16.41
UniProt:
Q9BY44
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY44
NP_114414.2
585
64990
S474
P
Q
N
M
K
P
Q
S
G
N
D
K
P
L
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001108004
580
64436
S469
P
Q
N
M
K
S
Q
S
G
N
D
K
P
L
S
Dog
Lupus familis
XP_534306
585
65159
A474
P
Q
N
M
K
P
Q
A
G
N
D
K
P
L
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJW6
581
64385
P474
P
Q
N
M
K
P
H
P
G
S
D
K
P
L
S
Rat
Rattus norvegicus
NP_001102809
541
60196
K455
Q
R
K
H
E
A
K
K
A
A
K
Q
E
A
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507598
493
54394
Q407
E
A
K
K
A
A
K
Q
E
A
R
N
D
G
G
Chicken
Gallus gallus
Q5ZKC1
586
64485
S474
P
Q
N
M
K
P
Q
S
G
S
S
E
K
P
L
Frog
Xenopus laevis
Q7ZY11
582
64798
S476
P
Q
S
M
M
P
Q
S
T
E
K
P
M
S
K
Zebra Danio
Brachydanio rerio
Q4QRJ7
580
64206
G473
P
P
Q
N
M
K
P
G
A
A
G
E
K
Q
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VNX8
638
70052
P490
P
S
I
P
G
L
A
P
T
A
A
A
G
G
V
Honey Bee
Apis mellifera
XP_625143
577
65273
K473
K
D
K
K
K
T
P
K
S
T
T
K
A
K
K
Nematode Worm
Caenorhab. elegans
Q19052
570
64001
G478
L
R
K
P
L
G
G
G
G
S
A
G
P
P
S
Sea Urchin
Strong. purpuratus
XP_001186352
299
33040
W212
L
R
G
H
I
Q
F
W
D
R
K
S
F
K
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53235
642
71286
A493
S
Q
H
P
S
R
E
A
S
S
N
G
N
G
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.4
96
N.A.
92.8
82.5
N.A.
74.5
84.4
74.8
69.5
N.A.
39
43.9
35.7
29.2
Protein Similarity:
100
N.A.
98.2
98.2
N.A.
95.5
87
N.A.
79.4
91.6
86.5
81.5
N.A.
56.5
61.3
54.8
40
P-Site Identity:
100
N.A.
93.3
93.3
N.A.
80
0
N.A.
0
60
40
6.6
N.A.
6.6
13.3
20
0
P-Site Similarity:
100
N.A.
93.3
100
N.A.
86.6
26.6
N.A.
6.6
73.3
46.6
13.3
N.A.
6.6
13.3
33.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
15
8
15
15
29
15
8
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
0
0
0
8
0
29
0
8
0
0
% D
% Glu:
8
0
0
0
8
0
8
0
8
8
0
15
8
0
0
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% F
% Gly:
0
0
8
0
8
8
8
15
43
0
8
15
8
22
8
% G
% His:
0
0
8
15
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
0
29
15
43
8
15
15
0
0
22
36
15
15
15
% K
% Leu:
15
0
0
0
8
8
0
0
0
0
0
0
0
29
15
% L
% Met:
0
0
0
43
15
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
36
8
0
0
0
0
0
22
8
8
8
0
0
% N
% Pro:
58
8
0
22
0
36
15
15
0
0
0
8
36
15
8
% P
% Gln:
8
50
8
0
0
8
36
8
0
0
0
8
0
8
0
% Q
% Arg:
0
22
0
0
0
8
0
0
0
8
8
0
0
0
8
% R
% Ser:
8
8
8
0
8
8
0
29
15
29
8
8
0
8
43
% S
% Thr:
0
0
0
0
0
8
0
0
15
8
8
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _