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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2A All Species: 9.7
Human Site: S474 Identified Species: 16.41
UniProt: Q9BY44 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BY44 NP_114414.2 585 64990 S474 P Q N M K P Q S G N D K P L S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001108004 580 64436 S469 P Q N M K S Q S G N D K P L S
Dog Lupus familis XP_534306 585 65159 A474 P Q N M K P Q A G N D K P L S
Cat Felis silvestris
Mouse Mus musculus Q8BJW6 581 64385 P474 P Q N M K P H P G S D K P L S
Rat Rattus norvegicus NP_001102809 541 60196 K455 Q R K H E A K K A A K Q E A R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507598 493 54394 Q407 E A K K A A K Q E A R N D G G
Chicken Gallus gallus Q5ZKC1 586 64485 S474 P Q N M K P Q S G S S E K P L
Frog Xenopus laevis Q7ZY11 582 64798 S476 P Q S M M P Q S T E K P M S K
Zebra Danio Brachydanio rerio Q4QRJ7 580 64206 G473 P P Q N M K P G A A G E K Q P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VNX8 638 70052 P490 P S I P G L A P T A A A G G V
Honey Bee Apis mellifera XP_625143 577 65273 K473 K D K K K T P K S T T K A K K
Nematode Worm Caenorhab. elegans Q19052 570 64001 G478 L R K P L G G G G S A G P P S
Sea Urchin Strong. purpuratus XP_001186352 299 33040 W212 L R G H I Q F W D R K S F K L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53235 642 71286 A493 S Q H P S R E A S S N G N G S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 97.4 96 N.A. 92.8 82.5 N.A. 74.5 84.4 74.8 69.5 N.A. 39 43.9 35.7 29.2
Protein Similarity: 100 N.A. 98.2 98.2 N.A. 95.5 87 N.A. 79.4 91.6 86.5 81.5 N.A. 56.5 61.3 54.8 40
P-Site Identity: 100 N.A. 93.3 93.3 N.A. 80 0 N.A. 0 60 40 6.6 N.A. 6.6 13.3 20 0
P-Site Similarity: 100 N.A. 93.3 100 N.A. 86.6 26.6 N.A. 6.6 73.3 46.6 13.3 N.A. 6.6 13.3 33.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 8 15 8 15 15 29 15 8 8 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 0 0 0 0 8 0 29 0 8 0 0 % D
% Glu: 8 0 0 0 8 0 8 0 8 8 0 15 8 0 0 % E
% Phe: 0 0 0 0 0 0 8 0 0 0 0 0 8 0 0 % F
% Gly: 0 0 8 0 8 8 8 15 43 0 8 15 8 22 8 % G
% His: 0 0 8 15 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 8 0 29 15 43 8 15 15 0 0 22 36 15 15 15 % K
% Leu: 15 0 0 0 8 8 0 0 0 0 0 0 0 29 15 % L
% Met: 0 0 0 43 15 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 0 0 36 8 0 0 0 0 0 22 8 8 8 0 0 % N
% Pro: 58 8 0 22 0 36 15 15 0 0 0 8 36 15 8 % P
% Gln: 8 50 8 0 0 8 36 8 0 0 0 8 0 8 0 % Q
% Arg: 0 22 0 0 0 8 0 0 0 8 8 0 0 0 8 % R
% Ser: 8 8 8 0 8 8 0 29 15 29 8 8 0 8 43 % S
% Thr: 0 0 0 0 0 8 0 0 15 8 8 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _