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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2A All Species: 15.15
Human Site: S506 Identified Species: 25.64
UniProt: Q9BY44 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BY44 NP_114414.2 585 64990 S506 Q E A R S D K S P D L A P T P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001108004 580 64436 S501 Q E A R S D K S P D L A P T P
Dog Lupus familis XP_534306 585 65159 S506 Q E A R N E K S P D L A P T P
Cat Felis silvestris
Mouse Mus musculus Q8BJW6 581 64385 R502 K A A K Q E A R S D A A P T P
Rat Rattus norvegicus NP_001102809 541 60196 S482 P R S T V T Q S A S G D P E V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507598 493 54394 P434 P R S A A P L P T S G D P E V
Chicken Gallus gallus Q5ZKC1 586 64485 S507 Q E A K A D C S Q E S T Q S S
Frog Xenopus laevis Q7ZY11 582 64798 P507 Q E S K M D E P A E S D S T N
Zebra Danio Brachydanio rerio Q4QRJ7 580 64206 A506 Q E N K P D E A P P P A A D P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VNX8 638 70052 R557 R K P Q H T P R Q K Y Q P D N
Honey Bee Apis mellifera XP_625143 577 65273 N503 Q S N N P S T N G Q V T T S T
Nematode Worm Caenorhab. elegans Q19052 570 64001 N506 A Q P R A N G N G N A P Q P F
Sea Urchin Strong. purpuratus XP_001186352 299 33040 H239 Q W S P D G Q H Y A T A I C A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53235 642 71286 S560 R R R A N K K S S E T S P D S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 97.4 96 N.A. 92.8 82.5 N.A. 74.5 84.4 74.8 69.5 N.A. 39 43.9 35.7 29.2
Protein Similarity: 100 N.A. 98.2 98.2 N.A. 95.5 87 N.A. 79.4 91.6 86.5 81.5 N.A. 56.5 61.3 54.8 40
P-Site Identity: 100 N.A. 100 86.6 N.A. 40 13.3 N.A. 6.6 33.3 26.6 40 N.A. 6.6 6.6 6.6 13.3
P-Site Similarity: 100 N.A. 100 100 N.A. 60 26.6 N.A. 20 60 53.3 60 N.A. 26.6 26.6 40 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 36 15 22 0 8 8 15 8 15 43 8 0 8 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 0 0 8 36 0 0 0 29 0 22 0 22 0 % D
% Glu: 0 43 0 0 0 15 15 0 0 22 0 0 0 15 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % F
% Gly: 0 0 0 0 0 8 8 0 15 0 15 0 0 0 0 % G
% His: 0 0 0 0 8 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % I
% Lys: 8 8 0 29 0 8 29 0 0 8 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 8 0 0 0 22 0 0 0 0 % L
% Met: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 15 8 15 8 0 15 0 8 0 0 0 0 15 % N
% Pro: 15 0 15 8 15 8 8 15 29 8 8 8 58 8 36 % P
% Gln: 58 8 0 8 8 0 15 0 15 8 0 8 15 0 0 % Q
% Arg: 15 22 8 29 0 0 0 15 0 0 0 0 0 0 0 % R
% Ser: 0 8 29 0 15 8 0 43 15 15 15 8 8 15 15 % S
% Thr: 0 0 0 8 0 15 8 0 8 0 15 15 8 36 8 % T
% Val: 0 0 0 0 8 0 0 0 0 0 8 0 0 0 15 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _