Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2A All Species: 43.03
Human Site: T374 Identified Species: 72.82
UniProt: Q9BY44 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BY44 NP_114414.2 585 64990 T374 P D G E H I L T A T C A P R L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001108004 580 64436 T369 P D G E H I L T A T C A P R L
Dog Lupus familis XP_534306 585 65159 T374 P D G E H I L T A T C A P R L
Cat Felis silvestris
Mouse Mus musculus Q8BJW6 581 64385 T374 P D G E H I L T A T C A P R L
Rat Rattus norvegicus NP_001102809 541 60196 S355 K I W H Y T G S L L Y K Y D V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507598 493 54394 L307 W H Y T G S V L H K Y D V P P
Chicken Gallus gallus Q5ZKC1 586 64485 T374 P D G E H I V T A T C A P R L
Frog Xenopus laevis Q7ZY11 582 64798 T376 P N G E H I I T A T C S P R L
Zebra Danio Brachydanio rerio Q4QRJ7 580 64206 T373 P D G E H I V T A T C S P R L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VNX8 638 70052 T390 P N G E W F V T A T T A P R L
Honey Bee Apis mellifera XP_625143 577 65273 T373 P D G E H F M T A T T A P R L
Nematode Worm Caenorhab. elegans Q19052 570 64001 T378 P D G Q H F V T C T T A P R L
Sea Urchin Strong. purpuratus XP_001186352 299 33040 D112 I V A T Q D V D T T G S S Y Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53235 642 71286 T393 P G G E F I M T A T T S P R L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 97.4 96 N.A. 92.8 82.5 N.A. 74.5 84.4 74.8 69.5 N.A. 39 43.9 35.7 29.2
Protein Similarity: 100 N.A. 98.2 98.2 N.A. 95.5 87 N.A. 79.4 91.6 86.5 81.5 N.A. 56.5 61.3 54.8 40
P-Site Identity: 100 N.A. 100 100 N.A. 100 0 N.A. 0 93.3 80 86.6 N.A. 66.6 80 66.6 6.6
P-Site Similarity: 100 N.A. 100 100 N.A. 100 20 N.A. 6.6 100 100 100 N.A. 80 86.6 80 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 66.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 0 0 72 0 0 58 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 50 0 0 0 0 % C
% Asp: 0 58 0 0 0 8 0 8 0 0 0 8 0 8 0 % D
% Glu: 0 0 0 72 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 8 22 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 79 0 8 0 8 0 0 0 8 0 0 0 0 % G
% His: 0 8 0 8 65 0 0 0 8 0 0 0 0 0 0 % H
% Ile: 8 8 0 0 0 58 8 0 0 0 0 0 0 0 0 % I
% Lys: 8 0 0 0 0 0 0 0 0 8 0 8 0 0 0 % K
% Leu: 0 0 0 0 0 0 29 8 8 8 0 0 0 0 79 % L
% Met: 0 0 0 0 0 0 15 0 0 0 0 0 0 0 0 % M
% Asn: 0 15 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 79 0 0 0 0 0 0 0 0 0 0 0 79 8 8 % P
% Gln: 0 0 0 8 8 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 79 0 % R
% Ser: 0 0 0 0 0 8 0 8 0 0 0 29 8 0 0 % S
% Thr: 0 0 0 15 0 8 0 79 8 86 29 0 0 0 0 % T
% Val: 0 8 0 0 0 0 43 0 0 0 0 0 8 0 8 % V
% Trp: 8 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 8 0 0 0 0 0 15 0 8 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _