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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2A
All Species:
19.7
Human Site:
Y112
Identified Species:
33.33
UniProt:
Q9BY44
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY44
NP_114414.2
585
64990
Y112
G
I
P
N
L
Q
L
Y
D
V
K
T
G
T
C
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001108004
580
64436
G112
Q
L
Y
D
V
K
T
G
T
C
L
K
S
F
I
Dog
Lupus familis
XP_534306
585
65159
Y112
G
I
P
N
L
Q
L
Y
D
V
K
T
G
T
C
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJW6
581
64385
Y112
G
T
P
N
L
Q
L
Y
D
M
K
T
G
A
C
Rat
Rattus norvegicus
NP_001102809
541
60196
V110
A
R
N
V
N
N
E
V
H
F
F
E
N
N
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507598
493
54394
F62
N
V
S
N
E
V
H
F
F
E
N
N
N
F
N
Chicken
Gallus gallus
Q5ZKC1
586
64485
Y112
G
A
P
N
L
Q
L
Y
D
V
K
T
G
K
C
Frog
Xenopus laevis
Q7ZY11
582
64798
Y112
G
T
P
N
L
Q
L
Y
D
L
K
S
G
K
I
Zebra Danio
Brachydanio rerio
Q4QRJ7
580
64206
D112
E
A
N
L
Q
L
W
D
L
Q
T
G
A
C
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VNX8
638
70052
Y124
G
S
P
N
L
L
V
Y
E
V
A
T
G
V
E
Honey Bee
Apis mellifera
XP_625143
577
65273
W112
G
I
A
N
L
H
I
W
K
S
E
T
G
E
L
Nematode Worm
Caenorhab. elegans
Q19052
570
64001
N113
E
N
Q
K
P
E
P
N
V
R
V
Y
S
L
A
Sea Urchin
Strong. purpuratus
XP_001186352
299
33040
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53235
642
71286
S117
P
F
K
K
D
C
V
S
E
D
I
V
P
A
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.4
96
N.A.
92.8
82.5
N.A.
74.5
84.4
74.8
69.5
N.A.
39
43.9
35.7
29.2
Protein Similarity:
100
N.A.
98.2
98.2
N.A.
95.5
87
N.A.
79.4
91.6
86.5
81.5
N.A.
56.5
61.3
54.8
40
P-Site Identity:
100
N.A.
0
100
N.A.
80
0
N.A.
6.6
86.6
66.6
0
N.A.
53.3
40
0
0
P-Site Similarity:
100
N.A.
26.6
100
N.A.
86.6
0
N.A.
20
86.6
80
0
N.A.
66.6
60
6.6
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
15
8
0
0
0
0
0
0
0
8
0
8
15
8
% A
% Cys:
0
0
0
0
0
8
0
0
0
8
0
0
0
8
29
% C
% Asp:
0
0
0
8
8
0
0
8
36
8
0
0
0
0
0
% D
% Glu:
15
0
0
0
8
8
8
0
15
8
8
8
0
8
8
% E
% Phe:
0
8
0
0
0
0
0
8
8
8
8
0
0
15
0
% F
% Gly:
50
0
0
0
0
0
0
8
0
0
0
8
50
0
0
% G
% His:
0
0
0
0
0
8
8
0
8
0
0
0
0
0
0
% H
% Ile:
0
22
0
0
0
0
8
0
0
0
8
0
0
0
15
% I
% Lys:
0
0
8
15
0
8
0
0
8
0
36
8
0
15
0
% K
% Leu:
0
8
0
8
50
15
36
0
8
8
8
0
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% M
% Asn:
8
8
15
58
8
8
0
8
0
0
8
8
15
8
15
% N
% Pro:
8
0
43
0
8
0
8
0
0
0
0
0
8
0
0
% P
% Gln:
8
0
8
0
8
36
0
0
0
8
0
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
0
8
8
0
0
0
0
8
0
8
0
8
15
0
0
% S
% Thr:
0
15
0
0
0
0
8
0
8
0
8
43
0
15
0
% T
% Val:
0
8
0
8
8
8
15
8
8
29
8
8
0
8
0
% V
% Trp:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
43
0
0
0
8
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _