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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2A
All Species:
25.45
Human Site:
Y203
Identified Species:
43.08
UniProt:
Q9BY44
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY44
NP_114414.2
585
64990
Y203
S
F
V
R
L
Y
Q
Y
P
N
F
A
G
P
H
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001108004
580
64436
Y198
S
F
V
R
L
Y
Q
Y
P
N
F
A
G
P
H
Dog
Lupus familis
XP_534306
585
65159
Y203
S
F
V
R
L
Y
Q
Y
P
N
F
D
G
P
H
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJW6
581
64385
Y203
S
F
V
R
L
Y
Q
Y
P
N
F
A
G
P
Q
Rat
Rattus norvegicus
NP_001102809
541
60196
V195
W
N
K
K
A
T
A
V
L
V
I
A
S
T
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507598
493
54394
V147
K
K
A
T
A
V
L
V
I
A
S
T
E
V
D
Chicken
Gallus gallus
Q5ZKC1
586
64485
Y203
S
F
V
R
L
Y
Q
Y
P
N
F
G
G
P
Q
Frog
Xenopus laevis
Q7ZY11
582
64798
Y205
S
F
V
R
L
Y
Q
Y
P
N
F
S
G
P
N
Zebra Danio
Brachydanio rerio
Q4QRJ7
580
64206
Y202
S
F
V
R
L
Y
Q
Y
P
N
F
G
G
P
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VNX8
638
70052
K219
P
S
M
C
K
L
Y
K
Y
P
A
L
G
Q
N
Honey Bee
Apis mellifera
XP_625143
577
65273
Q202
P
S
F
G
R
L
F
Q
Y
P
K
F
E
S
T
Nematode Worm
Caenorhab. elegans
Q19052
570
64001
H206
T
P
A
R
V
R
V
H
R
V
S
E
S
F
P
Sea Urchin
Strong. purpuratus
XP_001186352
299
33040
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53235
642
71286
I221
W
A
L
S
E
G
K
I
T
K
K
I
A
S
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.4
96
N.A.
92.8
82.5
N.A.
74.5
84.4
74.8
69.5
N.A.
39
43.9
35.7
29.2
Protein Similarity:
100
N.A.
98.2
98.2
N.A.
95.5
87
N.A.
79.4
91.6
86.5
81.5
N.A.
56.5
61.3
54.8
40
P-Site Identity:
100
N.A.
100
93.3
N.A.
93.3
6.6
N.A.
0
86.6
86.6
86.6
N.A.
6.6
0
6.6
0
P-Site Similarity:
100
N.A.
100
93.3
N.A.
93.3
13.3
N.A.
0
86.6
100
86.6
N.A.
20
0
26.6
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
15
0
15
0
8
0
0
8
8
29
8
0
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
15
% D
% Glu:
0
0
0
0
8
0
0
0
0
0
0
8
15
0
0
% E
% Phe:
0
50
8
0
0
0
8
0
0
0
50
8
0
8
0
% F
% Gly:
0
0
0
8
0
8
0
0
0
0
0
15
58
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
22
% H
% Ile:
0
0
0
0
0
0
0
8
8
0
8
8
0
0
0
% I
% Lys:
8
8
8
8
8
0
8
8
0
8
15
0
0
0
8
% K
% Leu:
0
0
8
0
50
15
8
0
8
0
0
8
0
0
0
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
50
0
0
0
0
15
% N
% Pro:
15
8
0
0
0
0
0
0
50
15
0
0
0
50
8
% P
% Gln:
0
0
0
0
0
0
50
8
0
0
0
0
0
8
15
% Q
% Arg:
0
0
0
58
8
8
0
0
8
0
0
0
0
0
0
% R
% Ser:
50
15
0
8
0
0
0
0
0
0
15
8
15
15
0
% S
% Thr:
8
0
0
8
0
8
0
0
8
0
0
8
0
8
15
% T
% Val:
0
0
50
0
8
8
8
15
0
15
0
0
0
8
0
% V
% Trp:
15
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
50
8
50
15
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _