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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2A
All Species:
26.67
Human Site:
Y400
Identified Species:
45.13
UniProt:
Q9BY44
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY44
NP_114414.2
585
64990
Y400
T
G
S
I
L
H
K
Y
D
V
P
S
N
A
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001108004
580
64436
Y395
T
G
S
I
L
H
K
Y
D
V
P
S
N
A
E
Dog
Lupus familis
XP_534306
585
65159
Y400
T
G
S
V
L
H
K
Y
D
M
P
S
N
A
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJW6
581
64385
Y400
T
G
S
L
L
H
K
Y
D
V
P
S
N
G
E
Rat
Rattus norvegicus
NP_001102809
541
60196
F381
Q
P
F
L
D
G
I
F
P
A
K
T
I
T
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507598
493
54394
A333
F
L
D
G
V
F
P
A
K
A
V
T
Y
Q
A
Chicken
Gallus gallus
Q5ZKC1
586
64485
Y400
T
G
S
V
L
H
N
Y
E
V
P
S
N
E
E
Frog
Xenopus laevis
Q7ZY11
582
64798
Y402
T
G
T
L
L
H
K
Y
D
V
P
A
N
S
E
Zebra Danio
Brachydanio rerio
Q4QRJ7
580
64206
H399
T
G
T
V
L
Y
K
H
E
T
P
S
G
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VNX8
638
70052
T416
S
G
A
L
L
H
E
T
M
W
P
Q
G
Q
E
Honey Bee
Apis mellifera
XP_625143
577
65273
R399
T
G
T
L
L
Y
E
R
P
W
N
E
Q
E
E
Nematode Worm
Caenorhab. elegans
Q19052
570
64001
T404
T
G
R
M
L
A
E
T
H
F
E
S
P
K
E
Sea Urchin
Strong. purpuratus
XP_001186352
299
33040
V138
G
D
S
S
N
V
T
V
G
K
K
G
P
V
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53235
642
71286
K419
S
G
S
L
V
F
V
K
E
F
K
E
L
L
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.4
96
N.A.
92.8
82.5
N.A.
74.5
84.4
74.8
69.5
N.A.
39
43.9
35.7
29.2
Protein Similarity:
100
N.A.
98.2
98.2
N.A.
95.5
87
N.A.
79.4
91.6
86.5
81.5
N.A.
56.5
61.3
54.8
40
P-Site Identity:
100
N.A.
100
86.6
N.A.
86.6
0
N.A.
0
73.3
73.3
46.6
N.A.
33.3
26.6
33.3
6.6
P-Site Similarity:
100
N.A.
100
100
N.A.
93.3
20
N.A.
13.3
86.6
100
80
N.A.
60
53.3
46.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
8
0
8
0
15
0
8
0
22
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
8
0
8
0
0
0
36
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
22
0
22
0
8
15
0
15
72
% E
% Phe:
8
0
8
0
0
15
0
8
0
15
0
0
0
0
0
% F
% Gly:
8
79
0
8
0
8
0
0
8
0
0
8
15
8
0
% G
% His:
0
0
0
0
0
50
0
8
8
0
0
0
0
0
0
% H
% Ile:
0
0
0
15
0
0
8
0
0
0
0
0
8
0
0
% I
% Lys:
0
0
0
0
0
0
43
8
8
8
22
0
0
15
8
% K
% Leu:
0
8
0
43
72
0
0
0
0
0
0
0
8
8
0
% L
% Met:
0
0
0
8
0
0
0
0
8
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
8
0
0
0
8
0
43
0
0
% N
% Pro:
0
8
0
0
0
0
8
0
15
0
58
0
15
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
0
0
0
8
8
15
0
% Q
% Arg:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% R
% Ser:
15
0
50
8
0
0
0
0
0
0
0
50
0
8
0
% S
% Thr:
65
0
22
0
0
0
8
15
0
8
0
15
0
8
0
% T
% Val:
0
0
0
22
15
8
8
8
0
36
8
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
15
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
15
0
43
0
0
0
0
8
0
15
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _