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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HES7 All Species: 13.33
Human Site: S146 Identified Species: 29.33
UniProt: Q9BYE0 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BYE0 NP_115969.2 225 24894 S146 R P P A P R P S L D P A A P A
Chimpanzee Pan troglodytes XP_001167471 225 24844 S146 R P P A P R P S L D P A A P A
Rhesus Macaque Macaca mulatta XP_001118139 272 29941 S193 R P P A P R P S L D P A A P A
Dog Lupus familis XP_850055 65 7913 L19 G P K M L K P L V E K R R R D
Cat Felis silvestris
Mouse Mus musculus Q8BKT2 225 24871 P146 G L P A P R P P L D P A S P I
Rat Rattus norvegicus Q03062 166 18434 F119 Q M K L L Y H F Q R P P A P A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509464 376 41515 Q209 R C P P A R P Q L D P A S P R
Chicken Gallus gallus O57337 290 31053 A162 N Y L P P P P A G Q P A H L A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6QB00 270 30843 Q197 D P T D L L C Q L E Y Q S P S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q26263 435 46532 T312 Q L P V K N S T S P P L S P I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_001001768 400 42683 T173 P L H A G Q P T V I F P S P A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 81.2 27.1 N.A. 92 32.4 N.A. 36.4 25.8 N.A. 21.4 N.A. 22.7 N.A. N.A. 24.7
Protein Similarity: 100 99.1 81.6 27.1 N.A. 94.2 41.3 N.A. 43.3 39.6 N.A. 33.3 N.A. 34 N.A. N.A. 33.2
P-Site Identity: 100 100 100 13.3 N.A. 66.6 26.6 N.A. 60 33.3 N.A. 20 N.A. 20 N.A. N.A. 26.6
P-Site Similarity: 100 100 100 33.3 N.A. 73.3 33.3 N.A. 66.6 40 N.A. 40 N.A. 40 N.A. N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 46 10 0 0 10 0 0 0 55 37 0 55 % A
% Cys: 0 10 0 0 0 0 10 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 10 0 0 0 0 0 46 0 0 0 0 10 % D
% Glu: 0 0 0 0 0 0 0 0 0 19 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 10 0 0 10 0 0 0 0 % F
% Gly: 19 0 0 0 10 0 0 0 10 0 0 0 0 0 0 % G
% His: 0 0 10 0 0 0 10 0 0 0 0 0 10 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 19 % I
% Lys: 0 0 19 0 10 10 0 0 0 0 10 0 0 0 0 % K
% Leu: 0 28 10 10 28 10 0 10 55 0 0 10 0 10 0 % L
% Met: 0 10 0 10 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 10 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % N
% Pro: 10 46 55 19 46 10 73 10 0 10 73 19 0 82 0 % P
% Gln: 19 0 0 0 0 10 0 19 10 10 0 10 0 0 0 % Q
% Arg: 37 0 0 0 0 46 0 0 0 10 0 10 10 10 10 % R
% Ser: 0 0 0 0 0 0 10 28 10 0 0 0 46 0 10 % S
% Thr: 0 0 10 0 0 0 0 19 0 0 0 0 0 0 0 % T
% Val: 0 0 0 10 0 0 0 0 19 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 0 0 0 10 0 0 0 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _