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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EDEM3 All Species: 8.79
Human Site: S846 Identified Species: 13.81
UniProt: Q9BZQ6 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.29
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BZQ6 NP_079467.3 932 104664 S846 S L N S H P E S L S L A D M D
Chimpanzee Pan troglodytes XP_514054 932 104646 L846 S L N S H P E L L S L A D V D
Rhesus Macaque Macaca mulatta XP_001113949 932 104559 S846 S L N S H P E S L S P A D M D
Dog Lupus familis XP_537162 933 104534 S847 S L N S Q P E S S S P T D T D
Cat Felis silvestris
Mouse Mus musculus Q2HXL6 931 104181 E845 H P A D S H S E A S P S D S E
Rat Rattus norvegicus XP_001070709 932 104212 P846 P L E S P S E P P S P A D S E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516152 1013 112746 P927 S L V S E P D P A S P V E A D
Chicken Gallus gallus XP_422293 1036 115091 D951 S S D V S D L D S L P P A Q A
Frog Xenopus laevis Q6GQB9 913 102717 P833 P V S Q P E V P S S D S P S G
Zebra Danio Brachydanio rerio XP_688275 861 96807 P788 R D H S S P A P S E P V D Q S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609611 801 90495 P728 G S S G E T Q P M F A M S G D
Honey Bee Apis mellifera XP_624812 952 107871 D877 I V K S R N E D S K I L K I S
Nematode Worm Caenorhab. elegans NP_509671 931 106447 Y852 H V T E L Q K Y L E F K D A D
Sea Urchin Strong. purpuratus XP_001188495 1088 121533 D982 P I H D V Q D D Q H I A Q S G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38888 796 91227 A723 I F S N A C D A V A S L Y S P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 99.1 97.3 N.A. 94.5 93.4 N.A. 80.8 76.4 78.6 69 N.A. 42.2 46.9 42.5 45.8
Protein Similarity: 100 99.6 99.2 98 N.A. 96.6 95.5 N.A. 85.7 81.8 86.5 80.6 N.A. 60.8 66.2 60.9 60.4
P-Site Identity: 100 86.6 93.3 66.6 N.A. 13.3 40 N.A. 40 6.6 6.6 20 N.A. 6.6 13.3 20 6.6
P-Site Similarity: 100 93.3 93.3 66.6 N.A. 26.6 46.6 N.A. 53.3 13.3 26.6 26.6 N.A. 26.6 33.3 33.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 43.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 7 0 7 7 14 7 7 34 7 14 7 % A
% Cys: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 7 14 0 7 20 20 0 0 7 0 54 0 47 % D
% Glu: 0 0 7 7 14 7 40 7 0 14 0 0 7 0 14 % E
% Phe: 0 7 0 0 0 0 0 0 0 7 7 0 0 0 0 % F
% Gly: 7 0 0 7 0 0 0 0 0 0 0 0 0 7 14 % G
% His: 14 0 14 0 20 7 0 0 0 7 0 0 0 0 0 % H
% Ile: 14 7 0 0 0 0 0 0 0 0 14 0 0 7 0 % I
% Lys: 0 0 7 0 0 0 7 0 0 7 0 7 7 0 0 % K
% Leu: 0 40 0 0 7 0 7 7 27 7 14 14 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 7 0 0 7 0 14 0 % M
% Asn: 0 0 27 7 0 7 0 0 0 0 0 0 0 0 0 % N
% Pro: 20 7 0 0 14 40 0 34 7 0 47 7 7 0 7 % P
% Gln: 0 0 0 7 7 14 7 0 7 0 0 0 7 14 0 % Q
% Arg: 7 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 40 14 20 54 20 7 7 20 34 54 7 14 7 34 14 % S
% Thr: 0 0 7 0 0 7 0 0 0 0 0 7 0 7 0 % T
% Val: 0 20 7 7 7 0 7 0 7 0 0 14 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 7 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _