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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPRY4
All Species:
24.55
Human Site:
S125
Identified Species:
54
UniProt:
Q9C004
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9C004
NP_001120968.1
299
32541
S125
P
P
V
A
D
Q
A
S
P
R
A
V
R
I
Q
Chimpanzee
Pan troglodytes
XP_527058
322
34921
S148
P
P
V
A
D
Q
A
S
P
R
A
V
R
I
Q
Rhesus Macaque
Macaca mulatta
XP_001095585
299
32472
S125
P
P
V
A
D
Q
A
S
P
R
A
V
R
I
Q
Dog
Lupus familis
XP_544320
318
34373
S144
P
P
V
A
D
Q
A
S
P
R
A
V
R
I
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9WTP2
300
32505
S126
P
P
V
A
E
Q
A
S
P
R
A
V
R
L
Q
Rat
Rattus norvegicus
Q3C2P8
410
46787
S153
T
T
A
T
D
S
S
S
N
S
S
Q
K
R
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510585
619
67001
T450
H
P
P
S
G
L
A
T
D
G
I
I
R
V
Q
Chicken
Gallus gallus
Q9PTL2
313
34398
E155
V
R
M
Q
P
K
S
E
L
K
S
S
E
L
K
Frog
Xenopus laevis
NP_001153153
319
35322
T149
R
S
A
S
G
H
R
T
E
R
I
V
R
M
Q
Zebra Danio
Brachydanio rerio
NP_571901
310
33718
A125
Q
R
L
L
D
H
A
A
P
T
P
V
V
D
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O44783
589
62370
A311
P
P
A
S
K
Q
P
A
P
P
R
L
G
M
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.6
97.9
87.4
N.A.
92.6
20
N.A.
26.9
40.8
42.9
60.6
N.A.
22.5
N.A.
N.A.
N.A.
Protein Similarity:
100
91.9
99
89.6
N.A.
95.6
32.4
N.A.
35.2
57.1
57.6
71.9
N.A.
33.4
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
86.6
13.3
N.A.
26.6
0
26.6
26.6
N.A.
26.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
40
N.A.
53.3
46.6
46.6
40
N.A.
53.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
28
46
0
0
64
19
0
0
46
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
55
0
0
0
10
0
0
0
0
10
0
% D
% Glu:
0
0
0
0
10
0
0
10
10
0
0
0
10
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
19
0
0
0
0
10
0
0
10
0
10
% G
% His:
10
0
0
0
0
19
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
19
10
0
37
0
% I
% Lys:
0
0
0
0
10
10
0
0
0
10
0
0
10
0
10
% K
% Leu:
0
0
10
10
0
10
0
0
10
0
0
10
0
19
0
% L
% Met:
0
0
10
0
0
0
0
0
0
0
0
0
0
19
0
% M
% Asn:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% N
% Pro:
55
64
10
0
10
0
10
0
64
10
10
0
0
0
10
% P
% Gln:
10
0
0
10
0
55
0
0
0
0
0
10
0
0
64
% Q
% Arg:
10
19
0
0
0
0
10
0
0
55
10
0
64
10
0
% R
% Ser:
0
10
0
28
0
10
19
55
0
10
19
10
0
0
0
% S
% Thr:
10
10
0
10
0
0
0
19
0
10
0
0
0
0
0
% T
% Val:
10
0
46
0
0
0
0
0
0
0
0
64
10
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _