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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF5A2
All Species:
10.91
Human Site:
Y127
Identified Species:
18.46
UniProt:
Q9GZV4
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9GZV4
NP_065123.1
153
16793
Y127
G
K
E
I
E
G
K
Y
N
A
G
E
D
V
Q
Chimpanzee
Pan troglodytes
XP_001174773
286
30517
Y259
G
K
E
I
E
Q
K
Y
D
C
G
E
E
I
L
Rhesus Macaque
Macaca mulatta
XP_001118011
190
21255
Y163
G
K
E
I
E
Q
K
Y
D
C
G
E
E
I
L
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
XP_001472697
357
39965
Y127
G
K
E
I
E
Q
K
Y
D
C
G
E
E
I
L
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q07460
153
16702
F127
G
K
E
I
E
G
K
F
N
A
N
E
D
V
Q
Frog
Xenopus laevis
NP_001080536
154
16686
H127
G
K
E
I
L
A
K
H
E
A
G
E
E
I
L
Zebra Danio
Brachydanio rerio
NP_998350
155
16861
F128
G
K
E
I
E
N
K
F
A
A
G
E
E
M
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9GU68
159
17573
F129
G
E
Q
L
R
L
D
F
D
S
G
K
D
L
L
Honey Bee
Apis mellifera
XP_624951
160
17574
H130
G
A
Q
L
R
A
D
H
E
A
G
K
E
L
L
Nematode Worm
Caenorhab. elegans
Q20751
161
17935
E133
Q
Q
I
R
D
A
Y
E
K
D
E
G
S
V
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P80639
160
17478
F132
V
A
Q
I
K
E
G
F
E
S
G
K
D
L
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XI91
158
17342
F130
L
Q
Q
I
K
S
G
F
D
D
G
K
D
L
V
Baker's Yeast
Sacchar. cerevisiae
P23301
157
17096
F128
G
D
S
L
Q
T
A
F
D
E
G
K
D
L
M
Red Bread Mold
Neurospora crassa
P38672
163
18017
E134
A
K
R
I
E
K
L
E
E
E
G
K
D
F
F
Conservation
Percent
Protein Identity:
100
45
66.8
N.A.
N.A.
33.8
N.A.
N.A.
N.A.
92.1
79.8
77.4
N.A.
65.4
67.5
59.6
N.A.
Protein Similarity:
100
50
75.2
N.A.
N.A.
40
N.A.
N.A.
N.A.
96.7
91.5
90.3
N.A.
81.7
78.1
73.2
N.A.
P-Site Identity:
100
60
60
N.A.
N.A.
60
N.A.
N.A.
N.A.
86.6
53.3
60
N.A.
20
20
6.6
N.A.
P-Site Similarity:
100
80
80
N.A.
N.A.
80
N.A.
N.A.
N.A.
93.3
73.3
80
N.A.
73.3
60
20
N.A.
Percent
Protein Identity:
N.A.
54.3
N.A.
57.5
61.7
60.7
Protein Similarity:
N.A.
70.6
N.A.
73.4
79.6
71.1
P-Site Identity:
N.A.
20
N.A.
20
20
33.3
P-Site Similarity:
N.A.
60
N.A.
66.6
60
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
15
0
0
0
22
8
0
8
36
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
22
0
0
0
0
0
% C
% Asp:
0
8
0
0
8
0
15
0
43
15
0
0
50
0
0
% D
% Glu:
0
8
50
0
50
8
0
15
29
15
8
50
43
0
0
% E
% Phe:
0
0
0
0
0
0
0
43
0
0
0
0
0
8
8
% F
% Gly:
72
0
0
0
0
15
15
0
0
0
86
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
15
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
72
0
0
0
0
0
0
0
0
0
29
0
% I
% Lys:
0
58
0
0
15
8
50
0
8
0
0
43
0
0
0
% K
% Leu:
8
0
0
22
8
8
8
0
0
0
0
0
0
36
58
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% M
% Asn:
0
0
0
0
0
8
0
0
15
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
15
29
0
8
22
0
0
0
0
0
0
0
0
15
% Q
% Arg:
0
0
8
8
15
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
8
0
0
8
0
0
0
15
0
0
8
0
0
% S
% Thr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% T
% Val:
8
0
0
0
0
0
0
0
0
0
0
0
0
22
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
29
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _