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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC22A4
All Species:
38.79
Human Site:
Y356
Identified Species:
77.58
UniProt:
Q9H015
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H015
NP_003050.2
551
62155
Y356
W
M
L
T
S
V
G
Y
F
A
L
S
L
D
A
Chimpanzee
Pan troglodytes
XP_001163062
551
62237
Y356
W
M
L
T
S
V
G
Y
F
A
L
S
L
D
A
Rhesus Macaque
Macaca mulatta
XP_001103789
557
62650
Y358
W
M
T
I
S
V
G
Y
F
G
L
S
L
D
T
Dog
Lupus familis
XP_531899
716
79502
Y521
W
M
L
T
S
V
G
Y
F
A
L
S
L
N
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z306
553
62272
Y358
W
M
L
T
S
V
G
Y
F
A
L
S
L
N
V
Rat
Rattus norvegicus
Q9R141
553
62344
Y358
W
M
L
T
S
V
G
Y
F
A
L
S
L
N
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510318
557
62019
Y358
W
M
T
I
S
V
G
Y
F
G
L
S
L
D
V
Chicken
Gallus gallus
NP_001139603
553
61767
Y358
W
F
F
T
S
V
G
Y
F
G
L
S
L
N
T
Frog
Xenopus laevis
Q66KG0
566
63736
Y365
W
F
T
G
S
L
G
Y
Y
V
F
A
L
N
S
Zebra Danio
Brachydanio rerio
Q6NYN7
560
61953
Y361
W
F
S
T
S
F
A
Y
Y
G
L
S
M
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCA2
548
60985
Y352
W
F
V
N
S
G
V
Y
Y
G
L
S
W
N
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U539
585
65444
Y374
W
V
M
N
A
I
I
Y
N
G
L
T
L
N
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
75.9
69.5
N.A.
84.8
85.3
N.A.
68.5
76.4
32.8
29.6
N.A.
36.1
N.A.
28
N.A.
Protein Similarity:
100
99.4
86.3
72.9
N.A.
92
92
N.A.
81.1
86.2
54.2
49.6
N.A.
56.4
N.A.
48.3
N.A.
P-Site Identity:
100
100
73.3
93.3
N.A.
86.6
86.6
N.A.
73.3
66.6
33.3
46.6
N.A.
33.3
N.A.
26.6
N.A.
P-Site Similarity:
100
100
73.3
100
N.A.
93.3
93.3
N.A.
73.3
73.3
66.6
60
N.A.
53.3
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
0
9
0
0
42
0
9
0
0
25
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
42
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
34
9
0
0
9
0
0
67
0
9
0
0
0
0
% F
% Gly:
0
0
0
9
0
9
75
0
0
50
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
17
0
9
9
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
42
0
0
9
0
0
0
0
92
0
84
0
9
% L
% Met:
0
59
9
0
0
0
0
0
0
0
0
0
9
0
0
% M
% Asn:
0
0
0
17
0
0
0
0
9
0
0
0
0
59
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
9
0
92
0
0
0
0
0
0
84
0
0
9
% S
% Thr:
0
0
25
59
0
0
0
0
0
0
0
9
0
0
25
% T
% Val:
0
9
9
0
0
67
9
0
0
9
0
0
0
0
34
% V
% Trp:
100
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% W
% Tyr:
0
0
0
0
0
0
0
100
25
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _