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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: XRN2 All Species: 13.03
Human Site: S784 Identified Species: 20.48
UniProt: Q9H0D6 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H0D6 NP_036387.2 950 108582 S784 P A A V L K P S D W E K S S N
Chimpanzee Pan troglodytes XP_514546 950 108522 S784 P A A V L K P S D W E K S S N
Rhesus Macaque Macaca mulatta XP_001094734 961 109718 S795 P A A V L K P S D W E K S S N
Dog Lupus familis XP_534324 950 108331 S784 P T P V L K P S D W E K S S N
Cat Felis silvestris
Mouse Mus musculus Q9DBR1 951 108669 G784 P A T V L K P G D W E K S S N
Rat Rattus norvegicus NP_001102066 561 63850 A424 P V H L D Q A A F R T L G H V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505862 950 108030 G784 P A P V L K P G D W E K S S N
Chicken Gallus gallus Q5ZIP4 949 108524 G783 P P P V L K P G D W E K T N N
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VM71 908 103942 Q756 E N A V D P P Q V L P N E Q S
Honey Bee Apis mellifera XP_392371 860 99367 I717 D A E T S I C I D G M R G T V
Nematode Worm Caenorhab. elegans Q9U299 975 110109 D812 P E K T L K P D D W N D R R D
Sea Urchin Strong. purpuratus XP_795068 1073 120270 E777 P D K V L K P E D F L N A N G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FQ03 1020 116807 N838 N N H G M H N N H G M H N N Q
Baker's Yeast Sacchar. cerevisiae Q02792 1006 115915 N863 R N K S I I L N G F I P S E P
Red Bread Mold Neurospora crassa Q8WZX5 1072 118291 L861 T R S D I D I L K G K A S R S
Conservation
Percent
Protein Identity: 100 99.7 97.6 98 N.A. 96 56.2 N.A. 91.1 82.9 N.A. N.A. N.A. 51.2 54 50.5 52.5
Protein Similarity: 100 99.8 98 99 N.A. 97 57.6 N.A. 95.4 90.5 N.A. N.A. N.A. 63.2 66.5 63.7 63.4
P-Site Identity: 100 100 100 86.6 N.A. 86.6 6.6 N.A. 86.6 66.6 N.A. N.A. N.A. 20 13.3 40 40
P-Site Similarity: 100 100 100 86.6 N.A. 86.6 26.6 N.A. 86.6 80 N.A. N.A. N.A. 26.6 26.6 46.6 60
Percent
Protein Identity: N.A. N.A. N.A. 42.6 40.5 40.8
Protein Similarity: N.A. N.A. N.A. 58 57.4 56.1
P-Site Identity: N.A. N.A. N.A. 0 6.6 6.6
P-Site Similarity: N.A. N.A. N.A. 26.6 26.6 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 40 27 0 0 0 7 7 0 0 0 7 7 0 0 % A
% Cys: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % C
% Asp: 7 7 0 7 14 7 0 7 67 0 0 7 0 0 7 % D
% Glu: 7 7 7 0 0 0 0 7 0 0 47 0 7 7 0 % E
% Phe: 0 0 0 0 0 0 0 0 7 14 0 0 0 0 0 % F
% Gly: 0 0 0 7 0 0 0 20 7 20 0 0 14 0 7 % G
% His: 0 0 14 0 0 7 0 0 7 0 0 7 0 7 0 % H
% Ile: 0 0 0 0 14 14 7 7 0 0 7 0 0 0 0 % I
% Lys: 0 0 20 0 0 60 0 0 7 0 7 47 0 0 0 % K
% Leu: 0 0 0 7 60 0 7 7 0 7 7 7 0 0 0 % L
% Met: 0 0 0 0 7 0 0 0 0 0 14 0 0 0 0 % M
% Asn: 7 20 0 0 0 0 7 14 0 0 7 14 7 20 47 % N
% Pro: 67 7 20 0 0 7 67 0 0 0 7 7 0 0 7 % P
% Gln: 0 0 0 0 0 7 0 7 0 0 0 0 0 7 7 % Q
% Arg: 7 7 0 0 0 0 0 0 0 7 0 7 7 14 0 % R
% Ser: 0 0 7 7 7 0 0 27 0 0 0 0 54 40 14 % S
% Thr: 7 7 7 14 0 0 0 0 0 0 7 0 7 7 0 % T
% Val: 0 7 0 60 0 0 0 0 7 0 0 0 0 0 14 % V
% Trp: 0 0 0 0 0 0 0 0 0 54 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _