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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOLLIP
All Species:
39.7
Human Site:
S155
Identified Species:
72.78
UniProt:
Q9H0E2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0E2
NP_061882.2
274
30282
S155
E
D
K
W
Y
S
L
S
G
R
Q
G
D
D
K
Chimpanzee
Pan troglodytes
XP_508213
280
30609
D170
D
G
W
M
F
L
L
D
P
G
T
I
S
A
V
Rhesus Macaque
Macaca mulatta
XP_001090075
274
30293
S155
E
D
K
W
Y
S
L
S
G
R
Q
G
D
D
K
Dog
Lupus familis
XP_540778
274
30050
S155
E
D
E
W
Y
S
L
S
G
R
Q
G
D
D
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ06
274
30326
S155
E
D
E
W
Y
S
L
S
G
R
Q
G
D
D
K
Rat
Rattus norvegicus
A2RUW1
274
30296
S155
E
D
E
W
Y
S
L
S
G
R
Q
G
D
D
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509306
280
31227
S164
E
D
E
W
Y
S
L
S
G
R
Q
G
D
D
K
Chicken
Gallus gallus
Q5ZK05
274
30521
S155
E
D
E
W
Y
S
L
S
G
R
Q
G
D
D
K
Frog
Xenopus laevis
Q3B8H2
269
29860
S155
V
D
E
W
F
S
L
S
G
R
Q
G
D
D
K
Zebra Danio
Brachydanio rerio
Q7ZV43
276
30405
S155
V
D
E
W
Y
S
L
S
G
R
Q
G
D
D
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624417
280
31837
L168
T
H
E
D
W
Y
M
L
S
G
K
Q
G
D
N
Nematode Worm
Caenorhab. elegans
NP_492757
243
27088
A140
A
H
I
M
L
P
L
A
I
F
N
G
D
N
I
Sea Urchin
Strong. purpuratus
XP_787012
307
33723
T167
K
D
D
W
F
P
L
T
G
K
Q
G
E
D
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.4
99.6
91.9
N.A.
92.6
93
N.A.
46.7
89
79.1
82.6
N.A.
N.A.
48.9
40.5
49.1
Protein Similarity:
100
84.6
99.6
97
N.A.
96.7
97
N.A.
56.7
94.5
88.6
92
N.A.
N.A.
64.6
61.3
66.1
P-Site Identity:
100
6.6
100
93.3
N.A.
93.3
93.3
N.A.
93.3
93.3
80
86.6
N.A.
N.A.
6.6
20
53.3
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
100
100
93.3
93.3
N.A.
N.A.
33.3
33.3
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
77
8
8
0
0
0
8
0
0
0
0
77
85
0
% D
% Glu:
54
0
62
0
0
0
0
0
0
0
0
0
8
0
0
% E
% Phe:
0
0
0
0
24
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
77
16
0
85
8
0
0
% G
% His:
0
16
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
8
0
0
8
0
0
8
% I
% Lys:
8
0
16
0
0
0
0
0
0
8
8
0
0
0
77
% K
% Leu:
0
0
0
0
8
8
93
8
0
0
0
0
0
0
0
% L
% Met:
0
0
0
16
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
8
% N
% Pro:
0
0
0
0
0
16
0
0
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
77
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
70
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
70
0
70
8
0
0
0
8
0
0
% S
% Thr:
8
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% T
% Val:
16
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
8
77
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
62
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _