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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TKTL2
All Species:
13.64
Human Site:
S280
Identified Species:
27.27
UniProt:
Q9H0I9
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0I9
NP_115512.3
626
67877
S280
A
I
V
K
L
I
E
S
Q
I
Q
T
N
E
N
Chimpanzee
Pan troglodytes
Q5R1W6
623
67821
S276
Q
I
I
Q
E
I
Y
S
Q
I
Q
S
K
K
K
Rhesus Macaque
Macaca mulatta
XP_001095403
703
76522
S357
A
I
V
K
L
I
E
S
Q
I
Q
T
N
E
N
Dog
Lupus familis
XP_538204
596
64805
E253
K
L
I
E
S
Q
I
E
T
N
K
N
L
E
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9D4D4
627
68429
N281
G
I
V
K
L
I
E
N
R
I
Q
T
N
R
N
Rat
Rattus norvegicus
P50137
623
67625
S276
Q
I
I
Q
E
I
Y
S
Q
V
Q
S
K
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508404
725
77819
T378
Q
I
V
Q
E
I
N
T
K
I
Q
S
K
K
K
Chicken
Gallus gallus
XP_414333
627
68436
E276
Q
V
I
Q
E
I
D
E
K
I
Q
N
K
K
K
Frog
Xenopus laevis
NP_001079885
625
67433
N279
S
I
I
N
E
I
Q
N
R
I
Q
T
N
K
K
Zebra Danio
Brachydanio rerio
NP_932336
625
67820
Q279
L
I
N
D
L
L
S
Q
I
Q
S
P
N
K
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623357
627
67899
K281
Q
H
L
T
G
M
L
K
N
P
G
P
L
G
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23254
680
73787
Q291
D
K
S
F
V
V
P
Q
E
V
Y
D
H
Y
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
66.1
85.9
75.4
N.A.
80.5
66.1
N.A.
56.8
66.5
72
69.3
N.A.
N.A.
60.1
N.A.
N.A.
Protein Similarity:
100
79.5
86.7
83
N.A.
89.4
79.5
N.A.
69
80.5
84.8
83.3
N.A.
N.A.
75.5
N.A.
N.A.
P-Site Identity:
100
40
100
6.6
N.A.
73.3
33.3
N.A.
33.3
20
40
20
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
100
66.6
100
33.3
N.A.
86.6
66.6
N.A.
66.6
60
80
33.3
N.A.
N.A.
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
25.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
9
0
0
9
0
0
0
0
9
0
0
0
% D
% Glu:
0
0
0
9
42
0
25
17
9
0
0
0
0
25
0
% E
% Phe:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
0
0
9
0
0
0
0
0
9
0
0
9
0
% G
% His:
0
9
0
0
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
0
67
42
0
0
67
9
0
9
59
0
0
0
0
0
% I
% Lys:
9
9
0
25
0
0
0
9
17
0
9
0
34
50
42
% K
% Leu:
9
9
9
0
34
9
9
0
0
0
0
0
17
0
9
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
9
0
0
9
17
9
9
0
17
42
0
25
% N
% Pro:
0
0
0
0
0
0
9
0
0
9
0
17
0
0
17
% P
% Gln:
42
0
0
34
0
9
9
17
34
9
67
0
0
0
9
% Q
% Arg:
0
0
0
0
0
0
0
0
17
0
0
0
0
9
0
% R
% Ser:
9
0
9
0
9
0
9
34
0
0
9
25
0
0
0
% S
% Thr:
0
0
0
9
0
0
0
9
9
0
0
34
0
0
0
% T
% Val:
0
9
34
0
9
9
0
0
0
17
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
17
0
0
0
9
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _