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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIK2 All Species: 16.06
Human Site: S451 Identified Species: 32.12
UniProt: Q9H0K1 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H0K1 NP_056006.1 926 103915 S451 P S N M M E T S I D E G L E T
Chimpanzee Pan troglodytes XP_508750 883 99166 S408 P S N M M E T S I D E G L E T
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_546528 993 110460 S526 P S N M M E T S I D E G L E T
Cat Felis silvestris
Mouse Mus musculus Q8CFH6 931 104180 S451 P S S M M E T S I D E G L E T
Rat Rattus norvegicus Q9R1U5 776 84890 Y338 Y N H F A A I Y Y L L L E R L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511894 801 88312 P364 S S Q L P G R P G T T R R H R
Chicken Gallus gallus Q9IA88 798 88848 Q361 S R P A T G R Q Q R P R S S E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 A568 P H P I P A V A P V D E E G S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_569972 1398 149888 A843 Q G N D P G S A S Q E S K G S
Honey Bee Apis mellifera XP_397175 718 80391 T281 T I C S M I I T R S S S S I Q
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 T659 S S A A Q P S T G I T G T R K
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 F75 E I K I L R L F M H P H I I R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.2 N.A. 84.7 N.A. 90.8 43.2 N.A. 45.2 45.4 N.A. 31.5 N.A. 29.6 37.4 23.8 N.A.
Protein Similarity: 100 95.3 N.A. 87.5 N.A. 94.4 56.7 N.A. 58.6 58.9 N.A. 45.2 N.A. 40 49.3 38.1 N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 93.3 0 N.A. 6.6 0 N.A. 6.6 N.A. 13.3 6.6 13.3 N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 100 13.3 N.A. 13.3 0 N.A. 33.3 N.A. 33.3 13.3 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 24.1 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 37.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 17 9 17 0 17 0 0 0 0 0 0 0 % A
% Cys: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 9 0 0 0 0 0 34 9 0 0 0 0 % D
% Glu: 9 0 0 0 0 34 0 0 0 0 42 9 17 34 9 % E
% Phe: 0 0 0 9 0 0 0 9 0 0 0 0 0 0 0 % F
% Gly: 0 9 0 0 0 25 0 0 17 0 0 42 0 17 0 % G
% His: 0 9 9 0 0 0 0 0 0 9 0 9 0 9 0 % H
% Ile: 0 17 0 17 0 9 17 0 34 9 0 0 9 17 0 % I
% Lys: 0 0 9 0 0 0 0 0 0 0 0 0 9 0 9 % K
% Leu: 0 0 0 9 9 0 9 0 0 9 9 9 34 0 9 % L
% Met: 0 0 0 34 42 0 0 0 9 0 0 0 0 0 0 % M
% Asn: 0 9 34 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 42 0 17 0 25 9 0 9 9 0 17 0 0 0 0 % P
% Gln: 9 0 9 0 9 0 0 9 9 9 0 0 0 0 9 % Q
% Arg: 0 9 0 0 0 9 17 0 9 9 0 17 9 17 17 % R
% Ser: 25 50 9 9 0 0 17 34 9 9 9 17 17 9 17 % S
% Thr: 9 0 0 0 9 0 34 17 0 9 17 0 9 0 34 % T
% Val: 0 0 0 0 0 0 9 0 0 9 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 9 9 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _