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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ANAPC1 All Species: 13.94
Human Site: S536 Identified Species: 27.88
UniProt: Q9H1A4 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H1A4 NP_073153.1 1944 216500 S536 S T P L D G V S T P K P L S K
Chimpanzee Pan troglodytes XP_515601 1394 155989 G52 V T L E L S N G S M V R I T I
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532958 1943 216470 S535 S T P L D S V S T P K P L S K
Cat Felis silvestris
Mouse Mus musculus P53995 1944 216068 G536 S T P L D G V G T P K P L S K
Rat Rattus norvegicus NP_001101241 1944 216060 S536 S T P L D G V S T P K P L S K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419303 1945 216100 T538 T P L D S V S T P S K T L N K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001921168 1979 220132 T536 T P L E N I S T P A R A T V Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_573025 2030 227256 S587 S G I P S G S S S F V E V R R
Honey Bee Apis mellifera XP_001122449 1939 218025 L528 K L H V T G I L P N L T G C N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001202400 910 100394
Poplar Tree Populus trichocarpa XP_002312165 1929 212815 C521 C N I I L Q M C R K P S A T S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_196175 1678 186257 N336 L Q T V E I N N E I L F D V K
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 71.5 N.A. 97.3 N.A. 92.1 92.9 N.A. N.A. 81.7 N.A. 66 N.A. 33.6 38 N.A. 25.2
Protein Similarity: 100 71.5 N.A. 98.5 N.A. 96 96.5 N.A. N.A. 90.2 N.A. 79 N.A. 52.2 59.1 N.A. 33.8
P-Site Identity: 100 6.6 N.A. 93.3 N.A. 93.3 100 N.A. N.A. 20 N.A. 0 N.A. 20 6.6 N.A. 0
P-Site Similarity: 100 26.6 N.A. 93.3 N.A. 93.3 100 N.A. N.A. 40 N.A. 33.3 N.A. 40 20 N.A. 0
Percent
Protein Identity: 28.5 N.A. N.A. 27.2 N.A. N.A.
Protein Similarity: 47 N.A. N.A. 45.8 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 20 N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 9 0 9 9 0 0 % A
% Cys: 9 0 0 0 0 0 0 9 0 0 0 0 0 9 0 % C
% Asp: 0 0 0 9 34 0 0 0 0 0 0 0 9 0 0 % D
% Glu: 0 0 0 17 9 0 0 0 9 0 0 9 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 9 0 9 0 0 0 % F
% Gly: 0 9 0 0 0 42 0 17 0 0 0 0 9 0 0 % G
% His: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 17 9 0 17 9 0 0 9 0 0 9 0 9 % I
% Lys: 9 0 0 0 0 0 0 0 0 9 42 0 0 0 50 % K
% Leu: 9 9 25 34 17 0 0 9 0 0 17 0 42 0 0 % L
% Met: 0 0 0 0 0 0 9 0 0 9 0 0 0 0 0 % M
% Asn: 0 9 0 0 9 0 17 9 0 9 0 0 0 9 9 % N
% Pro: 0 17 34 9 0 0 0 0 25 34 9 34 0 0 0 % P
% Gln: 0 9 0 0 0 9 0 0 0 0 0 0 0 0 9 % Q
% Arg: 0 0 0 0 0 0 0 0 9 0 9 9 0 9 9 % R
% Ser: 42 0 0 0 17 17 25 34 17 9 0 9 0 34 9 % S
% Thr: 17 42 9 0 9 0 0 17 34 0 0 17 9 17 0 % T
% Val: 9 0 0 17 0 9 34 0 0 0 17 0 9 17 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _