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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MYLK2
All Species:
7.27
Human Site:
S225
Identified Species:
20
UniProt:
Q9H1R3
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H1R3
NP_149109.1
596
64685
S225
A
K
M
Q
G
D
T
S
R
G
I
E
F
Q
A
Chimpanzee
Pan troglodytes
XP_527218
388
44535
P85
A
V
D
I
P
A
P
P
A
P
F
D
H
R
I
Rhesus Macaque
Macaca mulatta
XP_001113601
819
88691
S407
L
S
P
L
Q
E
S
S
S
P
R
G
A
K
S
Dog
Lupus familis
XP_534377
634
68610
S263
A
V
V
Q
G
D
T
S
R
G
I
E
F
Q
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8VCR8
613
65971
P242
A
K
V
Q
G
D
T
P
Q
R
I
G
F
Q
A
Rat
Rattus norvegicus
P20689
610
65798
A252
Q
A
V
P
S
E
R
A
E
V
G
Q
A
L
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521045
729
77615
A334
E
P
G
K
G
R
Q
A
G
S
A
T
S
E
A
Chicken
Gallus gallus
NP_990723
825
87195
T424
Q
P
I
P
A
G
S
T
A
V
P
Q
E
R
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001103990
555
61596
D219
I
K
I
S
S
A
T
D
K
N
S
A
Q
T
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
37.2
37.8
81.6
N.A.
80.9
80.8
N.A.
41.9
48.4
N.A.
40
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
49.5
50.9
86.1
N.A.
85.1
85.4
N.A.
54.7
58.2
N.A.
56.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
6.6
86.6
N.A.
66.6
0
N.A.
13.3
0
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
33.3
93.3
N.A.
80
26.6
N.A.
33.3
33.3
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
45
12
0
0
12
23
0
23
23
0
12
12
23
0
45
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% C
% Asp:
0
0
12
0
0
34
0
12
0
0
0
12
0
0
0
% D
% Glu:
12
0
0
0
0
23
0
0
12
0
0
23
12
12
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
12
0
34
0
0
% F
% Gly:
0
0
12
0
45
12
0
0
12
23
12
23
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% H
% Ile:
12
0
23
12
0
0
0
0
0
0
34
0
0
0
12
% I
% Lys:
0
34
0
12
0
0
0
0
12
0
0
0
0
12
12
% K
% Leu:
12
0
0
12
0
0
0
0
0
0
0
0
0
12
0
% L
% Met:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% N
% Pro:
0
23
12
23
12
0
12
23
0
23
12
0
0
0
0
% P
% Gln:
23
0
0
34
12
0
12
0
12
0
0
23
12
34
0
% Q
% Arg:
0
0
0
0
0
12
12
0
23
12
12
0
0
23
0
% R
% Ser:
0
12
0
12
23
0
23
34
12
12
12
0
12
0
12
% S
% Thr:
0
0
0
0
0
0
45
12
0
0
0
12
0
12
12
% T
% Val:
0
23
34
0
0
0
0
0
0
23
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _