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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
S1PR5
All Species:
5.76
Human Site:
S335
Identified Species:
12.67
UniProt:
Q9H228
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.4
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H228
NP_110387.1
398
41775
S335
C
G
R
D
P
S
G
S
Q
Q
S
A
S
A
A
Chimpanzee
Pan troglodytes
XP_513598
382
42768
R320
L
T
N
K
E
M
R
R
A
F
I
R
I
M
S
Rhesus Macaque
Macaca mulatta
XP_001101402
398
42060
S335
C
G
R
G
L
G
G
S
Q
K
S
G
S
A
A
Dog
Lupus familis
XP_854094
398
42211
S335
C
T
R
E
Q
D
A
S
Q
G
S
G
S
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q91X56
400
42312
Q338
Q
D
S
S
N
S
L
Q
R
S
P
S
A
A
G
Rat
Rattus norvegicus
Q9JKM5
400
42350
Q338
Q
D
S
S
N
S
L
Q
R
S
P
S
A
V
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520197
378
41947
R316
L
T
N
K
E
M
R
R
A
F
T
R
I
I
C
Chicken
Gallus gallus
XP_422305
379
42371
R317
L
T
N
K
E
M
R
R
A
F
I
K
I
L
C
Frog
Xenopus laevis
Q9PU17
366
41345
F298
I
L
A
Y
E
K
F
F
L
L
L
A
E
F
N
Zebra Danio
Brachydanio rerio
Q9DDK4
362
40583
N297
L
I
Y
T
L
T
S
N
E
M
R
R
A
F
I
Tiger Blowfish
Takifugu rubipres
Q9PUQ8
384
42694
K320
S
G
N
D
S
G
N
K
Q
F
Q
E
P
S
R
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
44.9
95.2
85.6
N.A.
85.7
87
N.A.
44.4
42.4
30.6
43.2
42.7
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
61
96.7
88.4
N.A.
89.2
90.5
N.A.
60.7
59.7
52
58.7
56.5
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
66.6
46.6
N.A.
13.3
6.6
N.A.
0
0
6.6
0
20
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
6.6
73.3
53.3
N.A.
33.3
26.6
N.A.
6.6
0
6.6
26.6
26.6
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
10
0
28
0
0
19
28
28
28
% A
% Cys:
28
0
0
0
0
0
0
0
0
0
0
0
0
0
19
% C
% Asp:
0
19
0
19
0
10
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
10
37
0
0
0
10
0
0
10
10
0
0
% E
% Phe:
0
0
0
0
0
0
10
10
0
37
0
0
0
19
0
% F
% Gly:
0
28
0
10
0
19
19
0
0
10
0
19
0
0
19
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
10
0
0
0
0
0
0
0
0
19
0
28
10
10
% I
% Lys:
0
0
0
28
0
10
0
10
0
10
0
10
0
0
0
% K
% Leu:
37
10
0
0
19
0
19
0
10
10
10
0
0
10
0
% L
% Met:
0
0
0
0
0
28
0
0
0
10
0
0
0
10
0
% M
% Asn:
0
0
37
0
19
0
10
10
0
0
0
0
0
0
10
% N
% Pro:
0
0
0
0
10
0
0
0
0
0
19
0
10
10
0
% P
% Gln:
19
0
0
0
10
0
0
19
37
10
10
0
0
0
0
% Q
% Arg:
0
0
28
0
0
0
28
28
19
0
10
28
0
0
10
% R
% Ser:
10
0
19
19
10
28
10
28
0
19
28
19
28
10
10
% S
% Thr:
0
37
0
10
0
10
0
0
0
0
10
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
10
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _