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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-4
All Species:
23.33
Human Site:
S271
Identified Species:
42.78
UniProt:
Q9H2Z4
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H2Z4
NP_149416.1
354
36179
S271
P
P
P
P
P
P
P
S
P
R
R
V
A
V
P
Chimpanzee
Pan troglodytes
XP_525278
419
42955
S336
P
P
P
P
P
P
P
S
P
R
R
V
A
V
P
Rhesus Macaque
Macaca mulatta
XP_001093634
451
46942
S368
P
P
P
P
P
P
P
S
P
R
R
V
A
V
P
Dog
Lupus familis
XP_849082
233
24205
G163
V
P
V
L
V
K
D
G
K
P
C
Q
N
G
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9EQM3
354
36207
S271
P
P
P
P
P
P
P
S
P
R
R
V
A
V
P
Rat
Rattus norvegicus
P23441
372
38536
S255
Q
Q
Q
A
Q
Q
Q
S
P
R
R
V
A
V
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
Y224
Y
N
V
S
I
N
P
Y
S
Y
N
A
Y
P
A
Frog
Xenopus laevis
P42587
196
22791
R126
N
H
R
Y
K
M
K
R
A
R
S
E
K
G
M
Zebra Danio
Brachydanio rerio
Q90481
269
30288
R198
V
T
H
L
P
S
P
R
R
V
A
V
P
V
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22808
723
76404
S631
H
H
P
S
A
L
P
S
P
R
R
V
A
V
P
Honey Bee
Apis mellifera
XP_394578
395
41030
S288
A
Q
N
Q
S
A
S
S
P
R
R
V
A
V
P
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
D229
D
G
S
S
P
P
P
D
N
D
D
D
D
D
K
Sea Urchin
Strong. purpuratus
NP_999800
411
44821
S334
K
A
S
P
V
E
P
S
S
C
G
I
P
I
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
84.2
77.1
61.2
N.A.
94.3
59.4
N.A.
N.A.
29.9
28.8
31
N.A.
24.3
37.9
31.6
38.9
Protein Similarity:
100
84.2
77.1
62.9
N.A.
94.6
66.4
N.A.
N.A.
42
38.4
42.9
N.A.
32
49.6
43.7
51.3
P-Site Identity:
100
100
100
6.6
N.A.
100
53.3
N.A.
N.A.
6.6
6.6
26.6
N.A.
66.6
53.3
20
20
P-Site Similarity:
100
100
100
6.6
N.A.
100
53.3
N.A.
N.A.
6.6
6.6
26.6
N.A.
66.6
53.3
20
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
8
8
8
0
0
8
0
8
8
54
0
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
8
8
0
8
8
8
8
8
0
% D
% Glu:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
8
0
0
8
0
0
16
0
% G
% His:
8
16
8
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
0
0
0
8
0
8
0
% I
% Lys:
8
0
0
0
8
8
8
0
8
0
0
0
8
0
8
% K
% Leu:
0
0
0
16
0
8
0
0
0
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% M
% Asn:
8
8
8
0
0
8
0
0
8
0
8
0
8
0
0
% N
% Pro:
31
39
39
39
47
39
70
0
54
8
0
0
16
8
54
% P
% Gln:
8
16
8
8
8
8
8
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
8
0
0
0
0
16
8
62
54
0
0
0
0
% R
% Ser:
0
0
16
24
8
8
8
62
16
0
8
0
0
0
8
% S
% Thr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
16
0
16
0
16
0
0
0
0
8
0
62
0
62
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
8
0
0
0
8
0
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _