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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-4
All Species:
16.97
Human Site:
S318
Identified Species:
31.11
UniProt:
Q9H2Z4
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H2Z4
NP_149416.1
354
36179
S318
E
L
E
E
L
S
P
S
P
P
A
L
H
G
P
Chimpanzee
Pan troglodytes
XP_525278
419
42955
S383
E
L
E
E
L
S
P
S
P
P
A
L
H
G
P
Rhesus Macaque
Macaca mulatta
XP_001093634
451
46942
S415
E
L
E
E
L
S
P
S
P
P
A
L
H
G
P
Dog
Lupus familis
XP_849082
233
24205
P204
S
P
P
A
L
H
A
P
G
A
G
L
A
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9EQM3
354
36207
S318
E
L
E
E
L
S
P
S
P
P
A
L
H
G
P
Rat
Rattus norvegicus
P23441
372
38536
S337
D
L
A
H
H
A
A
S
P
A
A
L
Q
G
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
N265
A
A
G
N
N
F
M
N
F
S
V
G
D
L
N
Frog
Xenopus laevis
P42587
196
22791
A167
K
A
Q
D
F
N
P
A
T
F
P
T
G
I
P
Zebra Danio
Brachydanio rerio
Q90481
269
30288
H240
Y
S
A
Q
S
L
Q
H
M
Q
Y
N
A
H
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22808
723
76404
A683
H
L
V
A
L
N
G
A
A
A
Y
Q
H
A
A
Honey Bee
Apis mellifera
XP_394578
395
41030
S332
A
P
H
M
T
A
A
S
S
P
H
G
S
H
H
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
N270
F
G
L
P
Y
P
P
N
A
A
A
A
A
A
A
Sea Urchin
Strong. purpuratus
NP_999800
411
44821
A375
S
L
H
H
Q
A
S
A
M
H
S
L
Y
S
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
84.2
77.1
61.2
N.A.
94.3
59.4
N.A.
N.A.
29.9
28.8
31
N.A.
24.3
37.9
31.6
38.9
Protein Similarity:
100
84.2
77.1
62.9
N.A.
94.6
66.4
N.A.
N.A.
42
38.4
42.9
N.A.
32
49.6
43.7
51.3
P-Site Identity:
100
100
100
13.3
N.A.
100
40
N.A.
N.A.
0
13.3
0
N.A.
20
13.3
13.3
20
P-Site Similarity:
100
100
100
13.3
N.A.
100
53.3
N.A.
N.A.
6.6
46.6
6.6
N.A.
33.3
20
20
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
16
16
16
0
24
24
24
16
31
47
8
24
16
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% D
% Glu:
31
0
31
31
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
8
0
0
0
8
8
0
0
8
8
0
0
0
0
0
% F
% Gly:
0
8
8
0
0
0
8
0
8
0
8
16
8
39
0
% G
% His:
8
0
16
16
8
8
0
8
0
8
8
0
39
16
8
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% I
% Lys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
54
8
0
47
8
0
0
0
0
0
54
0
8
8
% L
% Met:
0
0
0
8
0
0
8
0
16
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
8
16
0
16
0
0
0
8
0
0
8
% N
% Pro:
0
16
8
8
0
8
47
8
39
39
8
0
0
0
47
% P
% Gln:
0
0
8
8
8
0
8
0
0
8
0
8
8
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
16
8
0
0
8
31
8
47
8
8
8
0
8
16
0
% S
% Thr:
0
0
0
0
8
0
0
0
8
0
0
8
0
0
0
% T
% Val:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
8
0
0
0
0
0
16
0
8
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _