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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TPK1 All Species: 38.48
Human Site: S218 Identified Species: 65.13
UniProt: Q9H3S4 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H3S4 NP_071890.2 243 27265 S218 F G T L V S T S N T Y D G S G
Chimpanzee Pan troglodytes XP_519461 243 27275 S218 F G T L V S T S N T Y D G S G
Rhesus Macaque Macaca mulatta XP_001094591 327 35961 S302 F G T L V S T S N T Y D G S G
Dog Lupus familis XP_532737 208 22899 N184 G T L V S T S N T Y D G S G V
Cat Felis silvestris
Mouse Mus musculus Q9R0M5 243 27050 S218 F G T L V S T S N T Y D G S G
Rat Rattus norvegicus NP_001128466 243 27189 S218 F G T L V S T S N T Y D G S G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506978 182 20341 N158 G T L V S T S N T Y D G S D D
Chicken Gallus gallus XP_418875 244 26997 S219 F G T L V S T S N T Y D N S G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001006074 257 28841 S218 F G Q L V S T S N T Y E D H D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P30636 243 27296 S211 F G K L I S T S N E V T T S Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002302706 255 28531 S230 F G D L V S T S N L V Q G E K
Maize Zea mays NP_001152100 267 30322 S241 F G S M I S T S N I V Q S E K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_850424 267 30196 S233 F G G L I S T S N L V K E E I
Baker's Yeast Sacchar. cerevisiae P35202 319 36598 S287 V T G R V S S S N R F V G D N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 65.7 76.9 N.A. 89.3 86.8 N.A. 58 73.3 N.A. 59.5 N.A. N.A. N.A. 32 N.A.
Protein Similarity: 100 99.5 69.7 81.8 N.A. 95 93 N.A. 65.8 84.4 N.A. 74.3 N.A. N.A. N.A. 51.8 N.A.
P-Site Identity: 100 100 100 0 N.A. 100 100 N.A. 0 93.3 N.A. 66.6 N.A. N.A. N.A. 53.3 N.A.
P-Site Similarity: 100 100 100 26.6 N.A. 100 100 N.A. 26.6 93.3 N.A. 73.3 N.A. N.A. N.A. 60 N.A.
Percent
Protein Identity: 38.4 36.7 N.A. 36.3 28.5 N.A.
Protein Similarity: 58 57.3 N.A. 55 42.9 N.A.
P-Site Identity: 60 40 N.A. 46.6 33.3 N.A.
P-Site Similarity: 60 60 N.A. 53.3 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 0 0 0 0 0 0 15 43 8 15 15 % D
% Glu: 0 0 0 0 0 0 0 0 0 8 0 8 8 22 0 % E
% Phe: 79 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % F
% Gly: 15 79 15 0 0 0 0 0 0 0 0 15 50 8 43 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 0 22 0 0 0 0 8 0 0 0 0 8 % I
% Lys: 0 0 8 0 0 0 0 0 0 0 0 8 0 0 15 % K
% Leu: 0 0 15 72 0 0 0 0 0 15 0 0 0 0 0 % L
% Met: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 15 86 0 0 0 8 0 8 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 8 0 0 0 0 0 0 0 0 15 0 0 8 % Q
% Arg: 0 0 0 8 0 0 0 0 0 8 0 0 0 0 0 % R
% Ser: 0 0 8 0 15 86 22 86 0 0 0 0 22 50 0 % S
% Thr: 0 22 43 0 0 15 79 0 15 50 0 8 8 0 0 % T
% Val: 8 0 0 15 65 0 0 0 0 0 29 8 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 15 50 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _