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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPK1
All Species:
41.52
Human Site:
S74
Identified Species:
70.26
UniProt:
Q9H3S4
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H3S4
NP_071890.2
243
27265
S74
F
I
N
G
D
F
D
S
I
R
P
E
V
R
E
Chimpanzee
Pan troglodytes
XP_519461
243
27275
S74
F
I
N
G
D
F
D
S
I
R
P
E
V
R
E
Rhesus Macaque
Macaca mulatta
XP_001094591
327
35961
S158
F
I
N
G
D
F
D
S
I
R
P
E
V
R
E
Dog
Lupus familis
XP_532737
208
22899
G52
K
E
Y
Y
A
I
K
G
C
E
I
I
S
T
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9R0M5
243
27050
S74
F
V
S
G
D
F
D
S
I
R
P
E
V
K
E
Rat
Rattus norvegicus
NP_001128466
243
27189
S74
F
I
N
G
D
F
D
S
I
R
P
E
V
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506978
182
20341
K26
V
M
E
Y
Y
K
V
K
G
C
E
L
I
E
T
Chicken
Gallus gallus
XP_418875
244
26997
S75
Y
I
S
G
D
F
D
S
I
Q
P
E
V
K
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001006074
257
28841
S74
Y
I
N
G
D
F
D
S
I
L
P
E
V
K
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P30636
243
27296
S72
I
I
C
G
D
F
D
S
I
N
K
Q
I
D
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002302706
255
28531
S87
M
I
K
G
D
M
D
S
I
R
T
E
V
L
D
Maize
Zea mays
NP_001152100
267
30322
S98
I
I
E
G
D
M
D
S
I
R
P
E
V
K
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_850424
267
30196
S90
V
I
K
G
D
M
D
S
I
R
R
D
V
L
D
Baker's Yeast
Sacchar. cerevisiae
P35202
319
36598
S100
Y
I
I
G
D
L
D
S
L
S
E
K
V
Y
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
65.7
76.9
N.A.
89.3
86.8
N.A.
58
73.3
N.A.
59.5
N.A.
N.A.
N.A.
32
N.A.
Protein Similarity:
100
99.5
69.7
81.8
N.A.
95
93
N.A.
65.8
84.4
N.A.
74.3
N.A.
N.A.
N.A.
51.8
N.A.
P-Site Identity:
100
100
100
0
N.A.
80
93.3
N.A.
0
66.6
N.A.
73.3
N.A.
N.A.
N.A.
46.6
N.A.
P-Site Similarity:
100
100
100
0
N.A.
100
100
N.A.
13.3
93.3
N.A.
86.6
N.A.
N.A.
N.A.
60
N.A.
Percent
Protein Identity:
38.4
36.7
N.A.
36.3
28.5
N.A.
Protein Similarity:
58
57.3
N.A.
55
42.9
N.A.
P-Site Identity:
60
66.6
N.A.
53.3
40
N.A.
P-Site Similarity:
66.6
73.3
N.A.
66.6
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
15
% A
% Cys:
0
0
8
0
0
0
0
0
8
8
0
0
0
0
0
% C
% Asp:
0
0
0
0
86
0
86
0
0
0
0
8
0
8
15
% D
% Glu:
0
8
15
0
0
0
0
0
0
8
15
65
0
8
36
% E
% Phe:
36
0
0
0
0
58
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
86
0
0
0
8
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
15
79
8
0
0
8
0
0
79
0
8
8
15
0
0
% I
% Lys:
8
0
15
0
0
8
8
8
0
0
8
8
0
36
8
% K
% Leu:
0
0
0
0
0
8
0
0
8
8
0
8
0
15
8
% L
% Met:
8
8
0
0
0
22
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
36
0
0
0
0
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
58
0
0
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
58
8
0
0
22
0
% R
% Ser:
0
0
15
0
0
0
0
86
0
8
0
0
8
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
15
% T
% Val:
15
8
0
0
0
0
8
0
0
0
0
0
79
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
22
0
8
15
8
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _