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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN23
All Species:
13.03
Human Site:
S104
Identified Species:
31.85
UniProt:
Q9H3S7
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H3S7
NP_056281.1
1636
178974
S104
T
E
I
F
S
G
K
S
V
A
H
E
D
I
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001100428
1769
194164
S241
T
E
I
F
S
G
K
S
V
A
H
E
D
I
K
Dog
Lupus familis
XP_851530
1262
137623
Cat
Felis silvestris
Mouse
Mus musculus
Q6PB44
1692
185198
S104
T
E
I
F
S
G
K
S
V
S
H
E
D
I
K
Rat
Rattus norvegicus
O88902
1499
163435
I70
K
K
L
V
Q
M
K
I
Y
Y
F
A
A
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001345811
2003
220166
T104
T
E
I
F
S
G
K
T
V
T
H
E
D
I
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648722
1833
200310
V101
K
D
L
Y
H
S
A
V
H
E
V
T
D
L
R
Honey Bee
Apis mellifera
XP_623844
1770
200065
V105
R
D
T
Y
A
N
M
V
C
S
L
A
N
I
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796684
1298
141735
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SAN9
1012
112176
Conservation
Percent
Protein Identity:
100
N.A.
90.2
65.2
N.A.
88.7
79.9
N.A.
N.A.
N.A.
N.A.
54.2
N.A.
27.3
26.9
N.A.
32.1
Protein Similarity:
100
N.A.
90.7
67.3
N.A.
91.4
82.6
N.A.
N.A.
N.A.
N.A.
65.1
N.A.
43.4
44.3
N.A.
47.6
P-Site Identity:
100
N.A.
100
0
N.A.
93.3
6.6
N.A.
N.A.
N.A.
N.A.
80
N.A.
6.6
6.6
N.A.
0
P-Site Similarity:
100
N.A.
100
0
N.A.
100
26.6
N.A.
N.A.
N.A.
N.A.
86.6
N.A.
40
46.6
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
20.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
34.1
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
0
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
10
0
0
20
0
20
10
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
10
% C
% Asp:
0
20
0
0
0
0
0
0
0
0
0
0
50
0
0
% D
% Glu:
0
40
0
0
0
0
0
0
0
10
0
40
0
0
0
% E
% Phe:
0
0
0
40
0
0
0
0
0
0
10
0
0
0
0
% F
% Gly:
0
0
0
0
0
40
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
10
0
0
0
10
0
40
0
0
0
0
% H
% Ile:
0
0
40
0
0
0
0
10
0
0
0
0
0
50
0
% I
% Lys:
20
10
0
0
0
0
50
0
0
0
0
0
0
0
30
% K
% Leu:
0
0
20
0
0
0
0
0
0
0
10
0
0
10
0
% L
% Met:
0
0
0
0
0
10
10
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
0
0
0
0
0
10
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
20
% R
% Ser:
0
0
0
0
40
10
0
30
0
20
0
0
0
0
0
% S
% Thr:
40
0
10
0
0
0
0
10
0
10
0
10
0
0
0
% T
% Val:
0
0
0
10
0
0
0
20
40
0
10
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
20
0
0
0
0
10
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _