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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN23 All Species: 13.33
Human Site: S1549 Identified Species: 32.59
UniProt: Q9H3S7 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H3S7 NP_056281.1 1636 178974 S1549 S S S P P P L S S P L P E A P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001100428 1769 194164 S1682 S S S P P P L S S P L P E A P
Dog Lupus familis XP_851530 1262 137623 A1181 L P S P L P E A P Q P E E E Q
Cat Felis silvestris
Mouse Mus musculus Q6PB44 1692 185198 S1605 S S S P P P L S S P L P E A P
Rat Rattus norvegicus O88902 1499 163435 S1412 P S S P P P P S S P L P E P P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001345811 2003 220166 L1878 L Q P S Q D P L C C E T M P D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648722 1833 200310 A1739 S E R S E L V A I G V C A I I
Honey Bee Apis mellifera XP_623844 1770 200065 Y1673 F A Y Q L V L Y H A Q D I L M
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796684 1298 141735 Q1217 L K S Q P Q P Q Q T S M Q Q T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SAN9 1012 112176 G931 P G G Y V P P G F V P P P P P
Conservation
Percent
Protein Identity: 100 N.A. 90.2 65.2 N.A. 88.7 79.9 N.A. N.A. N.A. N.A. 54.2 N.A. 27.3 26.9 N.A. 32.1
Protein Similarity: 100 N.A. 90.7 67.3 N.A. 91.4 82.6 N.A. N.A. N.A. N.A. 65.1 N.A. 43.4 44.3 N.A. 47.6
P-Site Identity: 100 N.A. 100 26.6 N.A. 100 80 N.A. N.A. N.A. N.A. 0 N.A. 6.6 6.6 N.A. 13.3
P-Site Similarity: 100 N.A. 100 33.3 N.A. 100 80 N.A. N.A. N.A. N.A. 0 N.A. 26.6 13.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 20.6
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 34.1
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 20
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 0 0 0 20 0 10 0 0 10 30 0 % A
% Cys: 0 0 0 0 0 0 0 0 10 10 0 10 0 0 0 % C
% Asp: 0 0 0 0 0 10 0 0 0 0 0 10 0 0 10 % D
% Glu: 0 10 0 0 10 0 10 0 0 0 10 10 50 10 0 % E
% Phe: 10 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % F
% Gly: 0 10 10 0 0 0 0 10 0 10 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 10 0 0 0 10 10 10 % I
% Lys: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 30 0 0 0 20 10 40 10 0 0 40 0 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 10 0 10 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 20 10 10 50 50 60 40 0 10 40 20 50 10 30 50 % P
% Gln: 0 10 0 20 10 10 0 10 10 10 10 0 10 10 10 % Q
% Arg: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 40 40 60 20 0 0 0 40 40 0 10 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 10 0 10 0 0 10 % T
% Val: 0 0 0 0 10 10 10 0 0 10 10 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 10 0 0 0 10 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _