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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN23 All Species: 22.12
Human Site: S193 Identified Species: 54.07
UniProt: Q9H3S7 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H3S7 NP_056281.1 1636 178974 S193 Q E C L L E K S M L D N R K S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001100428 1769 194164 S330 Q E C L L E K S M L D N R K S
Dog Lupus familis XP_851530 1262 137623
Cat Felis silvestris
Mouse Mus musculus Q6PB44 1692 185198 S193 Q E C L L E K S M L D N R K S
Rat Rattus norvegicus O88902 1499 163435 Q156 V P A L D T L Q P V K G A P L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001345811 2003 220166 S193 Q E C L L E K S M L D N R K S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648722 1833 200310 S192 Q E C I L E K S L I D N R K P
Honey Bee Apis mellifera XP_623844 1770 200065 S194 Q E C I L E K S M L D N R K P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796684 1298 141735 Q40 T L K K Y Y G Q L H L L S S R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SAN9 1012 112176
Conservation
Percent
Protein Identity: 100 N.A. 90.2 65.2 N.A. 88.7 79.9 N.A. N.A. N.A. N.A. 54.2 N.A. 27.3 26.9 N.A. 32.1
Protein Similarity: 100 N.A. 90.7 67.3 N.A. 91.4 82.6 N.A. N.A. N.A. N.A. 65.1 N.A. 43.4 44.3 N.A. 47.6
P-Site Identity: 100 N.A. 100 0 N.A. 100 6.6 N.A. N.A. N.A. N.A. 100 N.A. 73.3 86.6 N.A. 0
P-Site Similarity: 100 N.A. 100 0 N.A. 100 13.3 N.A. N.A. N.A. N.A. 100 N.A. 93.3 93.3 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 20.6
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 34.1
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 0
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 0
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 0 0 0 0 0 0 0 10 0 0 % A
% Cys: 0 0 60 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 10 0 0 0 0 0 60 0 0 0 0 % D
% Glu: 0 60 0 0 0 60 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 10 0 0 0 0 10 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % H
% Ile: 0 0 0 20 0 0 0 0 0 10 0 0 0 0 0 % I
% Lys: 0 0 10 10 0 0 60 0 0 0 10 0 0 60 0 % K
% Leu: 0 10 0 50 60 0 10 0 20 50 10 10 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 50 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 60 0 0 0 % N
% Pro: 0 10 0 0 0 0 0 0 10 0 0 0 0 10 20 % P
% Gln: 60 0 0 0 0 0 0 20 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 60 0 10 % R
% Ser: 0 0 0 0 0 0 0 60 0 0 0 0 10 10 40 % S
% Thr: 10 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % T
% Val: 10 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 10 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _