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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN23
All Species:
11.52
Human Site:
T542
Identified Species:
28.15
UniProt:
Q9H3S7
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H3S7
NP_056281.1
1636
178974
T542
Q
V
R
A
A
L
P
T
P
A
L
S
P
E
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001100428
1769
194164
T679
Q
V
R
A
A
L
P
T
P
A
L
T
P
E
D
Dog
Lupus familis
XP_851530
1262
137623
N304
L
E
K
S
M
L
D
N
R
K
S
F
L
V
A
Cat
Felis silvestris
Mouse
Mus musculus
Q6PB44
1692
185198
T544
Q
V
R
A
A
L
P
T
P
A
L
T
P
E
D
Rat
Rattus norvegicus
O88902
1499
163435
L457
Q
D
N
V
L
R
A
L
T
E
A
N
V
Q
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001345811
2003
220166
R540
T
L
R
E
A
L
P
R
P
Q
L
S
E
D
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648722
1833
200310
K543
E
I
Q
Q
L
M
P
K
L
S
S
E
L
N
T
Honey Bee
Apis mellifera
XP_623844
1770
200065
S529
D
L
I
A
H
I
P
S
P
S
A
Y
L
S
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796684
1298
141735
K340
L
Y
S
E
E
K
A
K
L
L
R
R
V
V
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SAN9
1012
112176
G54
R
L
R
Q
D
M
R
G
A
G
K
D
S
T
S
Conservation
Percent
Protein Identity:
100
N.A.
90.2
65.2
N.A.
88.7
79.9
N.A.
N.A.
N.A.
N.A.
54.2
N.A.
27.3
26.9
N.A.
32.1
Protein Similarity:
100
N.A.
90.7
67.3
N.A.
91.4
82.6
N.A.
N.A.
N.A.
N.A.
65.1
N.A.
43.4
44.3
N.A.
47.6
P-Site Identity:
100
N.A.
93.3
6.6
N.A.
93.3
6.6
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
6.6
20
N.A.
6.6
P-Site Similarity:
100
N.A.
100
20
N.A.
100
20
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
40
53.3
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
20.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
34.1
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
40
40
0
20
0
10
30
20
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
10
0
0
10
0
10
0
0
0
0
10
0
10
40
% D
% Glu:
10
10
0
20
10
0
0
0
0
10
0
10
10
30
20
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
10
0
10
0
0
0
0
0
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
10
0
0
10
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
10
0
0
10
0
20
0
10
10
0
0
0
0
% K
% Leu:
20
30
0
0
20
50
0
10
20
10
40
0
30
0
0
% L
% Met:
0
0
0
0
10
20
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
10
0
0
0
10
0
10
0
% N
% Pro:
0
0
0
0
0
0
60
0
50
0
0
0
30
0
0
% P
% Gln:
40
0
10
20
0
0
0
0
0
10
0
0
0
10
0
% Q
% Arg:
10
0
50
0
0
10
10
10
10
0
10
10
0
0
0
% R
% Ser:
0
0
10
10
0
0
0
10
0
20
20
20
10
10
10
% S
% Thr:
10
0
0
0
0
0
0
30
10
0
0
20
0
10
10
% T
% Val:
0
30
0
10
0
0
0
0
0
0
0
0
20
20
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
0
0
0
0
10
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _