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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN23
All Species:
17.27
Human Site:
Y214
Identified Species:
42.22
UniProt:
Q9H3S7
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H3S7
NP_056281.1
1636
178974
Y214
S
A
Q
V
V
D
Y
Y
K
E
A
C
R
A
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001100428
1769
194164
Y351
S
A
Q
V
V
D
Y
Y
K
E
A
C
R
A
L
Dog
Lupus familis
XP_851530
1262
137623
P25
A
E
G
R
P
A
G
P
P
G
R
P
G
K
E
Cat
Felis silvestris
Mouse
Mus musculus
Q6PB44
1692
185198
Y214
S
A
Q
V
V
D
Y
Y
K
E
A
C
R
A
L
Rat
Rattus norvegicus
O88902
1499
163435
T177
N
P
T
D
P
A
V
T
G
P
D
I
F
A
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001345811
2003
220166
Y214
S
A
Q
V
V
D
Y
Y
K
E
A
C
R
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648722
1833
200310
Y213
T
A
Q
I
V
V
Y
Y
G
A
A
L
A
A
L
Honey Bee
Apis mellifera
XP_623844
1770
200065
F215
A
R
Q
I
V
D
Y
F
N
L
A
L
T
T
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796684
1298
141735
F61
T
F
S
W
I
D
T
F
D
E
E
P
Y
T
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SAN9
1012
112176
Conservation
Percent
Protein Identity:
100
N.A.
90.2
65.2
N.A.
88.7
79.9
N.A.
N.A.
N.A.
N.A.
54.2
N.A.
27.3
26.9
N.A.
32.1
Protein Similarity:
100
N.A.
90.7
67.3
N.A.
91.4
82.6
N.A.
N.A.
N.A.
N.A.
65.1
N.A.
43.4
44.3
N.A.
47.6
P-Site Identity:
100
N.A.
100
0
N.A.
100
6.6
N.A.
N.A.
N.A.
N.A.
100
N.A.
53.3
40
N.A.
13.3
P-Site Similarity:
100
N.A.
100
6.6
N.A.
100
13.3
N.A.
N.A.
N.A.
N.A.
100
N.A.
66.6
60
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
20.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
34.1
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
0
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
50
0
0
0
20
0
0
0
10
60
0
10
60
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
40
0
0
0
% C
% Asp:
0
0
0
10
0
60
0
0
10
0
10
0
0
0
0
% D
% Glu:
0
10
0
0
0
0
0
0
0
50
10
0
0
0
10
% E
% Phe:
0
10
0
0
0
0
0
20
0
0
0
0
10
0
0
% F
% Gly:
0
0
10
0
0
0
10
0
20
10
0
0
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% H
% Ile:
0
0
0
20
10
0
0
0
0
0
0
10
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
40
0
0
0
0
10
10
% K
% Leu:
0
0
0
0
0
0
0
0
0
10
0
20
0
0
60
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% N
% Pro:
0
10
0
0
20
0
0
10
10
10
0
20
0
0
0
% P
% Gln:
0
0
60
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
10
0
10
0
0
0
0
0
0
10
0
40
0
0
% R
% Ser:
40
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
20
0
10
0
0
0
10
10
0
0
0
0
10
20
0
% T
% Val:
0
0
0
40
60
10
10
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
60
50
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _