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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FZD8
All Species:
18.18
Human Site:
S180
Identified Species:
36.36
UniProt:
Q9H461
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H461
NP_114072.1
694
73300
S180
G
E
Q
P
P
S
G
S
G
H
G
R
P
P
G
Chimpanzee
Pan troglodytes
XP_001142144
668
70462
G204
K
A
R
P
P
G
G
G
A
A
P
C
E
P
G
Rhesus Macaque
Macaca mulatta
XP_001096837
635
68033
S180
G
E
Q
P
P
S
G
S
G
H
G
R
P
P
G
Dog
Lupus familis
XP_545614
589
64543
R161
E
A
T
T
A
P
P
R
P
F
P
A
K
P
T
Cat
Felis silvestris
Mouse
Mus musculus
Q61091
685
73197
S181
G
E
Q
P
P
S
G
S
G
H
S
R
P
P
G
Rat
Rattus norvegicus
Q498S8
684
72990
S180
G
E
Q
P
P
S
G
S
G
H
S
R
P
P
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q9IA06
523
59263
K94
G
C
E
A
L
M
N
K
F
G
F
Q
W
P
E
Frog
Xenopus laevis
O93274
581
65360
A153
N
R
T
E
Q
T
T
A
A
P
S
H
P
E
P
Zebra Danio
Brachydanio rerio
NP_570993
579
65231
S151
M
D
Y
N
R
T
D
S
T
T
V
S
P
V
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVX3
694
75433
S213
G
K
R
K
Q
G
G
S
G
S
G
G
S
G
A
Honey Bee
Apis mellifera
XP_397259
711
74000
S248
Q
P
R
P
T
R
P
S
K
T
T
Q
P
P
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001188449
555
62346
Q127
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.9
86.3
59.7
N.A.
95.5
95.8
N.A.
N.A.
40.6
70.6
71
N.A.
50.4
47.5
N.A.
53.4
Protein Similarity:
100
96.1
88.1
67.4
N.A.
95.9
96.2
N.A.
N.A.
52.5
75.6
76.5
N.A.
60.8
58.2
N.A.
63.2
P-Site Identity:
100
33.3
100
6.6
N.A.
93.3
93.3
N.A.
N.A.
13.3
6.6
13.3
N.A.
33.3
26.6
N.A.
20
P-Site Similarity:
100
40
100
6.6
N.A.
93.3
93.3
N.A.
N.A.
26.6
20
26.6
N.A.
46.6
40
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
17
9
9
9
0
0
9
17
9
0
17
0
0
9
% A
% Cys:
0
17
0
0
0
0
0
0
0
0
0
9
0
0
0
% C
% Asp:
0
9
0
0
0
0
9
0
0
0
0
0
0
0
9
% D
% Glu:
9
34
9
9
0
0
0
0
0
0
0
0
9
9
9
% E
% Phe:
0
0
0
0
0
0
0
0
9
9
17
0
0
0
0
% F
% Gly:
59
0
0
0
0
17
50
9
42
17
25
9
0
9
42
% G
% His:
0
0
0
0
0
0
0
0
0
34
0
9
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
9
9
0
9
0
0
0
9
9
0
0
0
9
0
0
% K
% Leu:
0
0
0
0
17
0
0
0
0
0
0
0
0
0
9
% L
% Met:
9
0
0
0
0
17
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
0
0
9
0
0
9
0
0
0
0
0
0
0
0
% N
% Pro:
0
9
0
59
42
9
17
0
9
9
17
0
59
75
9
% P
% Gln:
9
0
34
0
17
0
0
9
0
0
0
17
0
0
0
% Q
% Arg:
0
9
25
0
9
9
9
9
0
0
0
34
0
0
9
% R
% Ser:
0
0
0
0
0
34
0
59
0
9
25
9
9
0
0
% S
% Thr:
0
0
17
9
9
17
9
0
9
17
9
0
0
0
9
% T
% Val:
0
0
0
0
0
0
0
0
0
0
9
0
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
17
0
0
% W
% Tyr:
0
0
9
0
0
0
0
0
9
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _