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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FZD8 All Species: 14.55
Human Site: S667 Identified Species: 29.09
UniProt: Q9H461 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H461 NP_114072.1 694 73300 S667 G G G G S L Y S D V S T G L T
Chimpanzee Pan troglodytes XP_001142144 668 70462 S641 G G G G S L Y S D V S T G L T
Rhesus Macaque Macaca mulatta XP_001096837 635 68033 G606 A Q P S E V R G A L W K G L T
Dog Lupus familis XP_545614 589 64543 T563 Y E A S A A L T G R T G P P G
Cat Felis silvestris
Mouse Mus musculus Q61091 685 73197 S658 G G G G S L Y S D V S T G L T
Rat Rattus norvegicus Q498S8 684 72990 S657 G G G G S L Y S D V S T G L T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q9IA06 523 59263 I497 G I T S G F W I F S G K T L H
Frog Xenopus laevis O93274 581 65360 D555 T G G S M Y S D V S T G L T W
Zebra Danio Brachydanio rerio NP_570993 579 65231 D553 S G G S M Y S D V S T G L T W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VVX3 694 75433 A662 S A A G S L L A T P Y T Q A G
Honey Bee Apis mellifera XP_397259 711 74000 G679 V P Y P P A P G P G S A L L P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188449 555 62346 G529 G F V N R L L G R K S Y P K R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.9 86.3 59.7 N.A. 95.5 95.8 N.A. N.A. 40.6 70.6 71 N.A. 50.4 47.5 N.A. 53.4
Protein Similarity: 100 96.1 88.1 67.4 N.A. 95.9 96.2 N.A. N.A. 52.5 75.6 76.5 N.A. 60.8 58.2 N.A. 63.2
P-Site Identity: 100 100 20 0 N.A. 100 100 N.A. N.A. 13.3 13.3 13.3 N.A. 26.6 13.3 N.A. 20
P-Site Similarity: 100 100 33.3 20 N.A. 100 100 N.A. N.A. 20 20 20 N.A. 33.3 13.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 17 0 9 17 0 9 9 0 0 9 0 9 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 17 34 0 0 0 0 0 0 % D
% Glu: 0 9 0 0 9 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 9 0 0 0 9 0 0 9 0 0 0 0 0 0 % F
% Gly: 50 50 50 42 9 0 0 25 9 9 9 25 42 0 17 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % H
% Ile: 0 9 0 0 0 0 0 9 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 9 0 17 0 9 0 % K
% Leu: 0 0 0 0 0 50 25 0 0 9 0 0 25 59 0 % L
% Met: 0 0 0 0 17 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 9 9 9 9 0 9 0 9 9 0 0 17 9 9 % P
% Gln: 0 9 0 0 0 0 0 0 0 0 0 0 9 0 0 % Q
% Arg: 0 0 0 0 9 0 9 0 9 9 0 0 0 0 9 % R
% Ser: 17 0 0 42 42 0 17 34 0 25 50 0 0 0 0 % S
% Thr: 9 0 9 0 0 0 0 9 9 0 25 42 9 17 42 % T
% Val: 9 0 9 0 0 9 0 0 17 34 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 9 0 0 0 9 0 0 0 17 % W
% Tyr: 9 0 9 0 0 17 34 0 0 0 9 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _