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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FZD8 All Species: 17.58
Human Site: T390 Identified Species: 35.15
UniProt: Q9H461 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H461 NP_114072.1 694 73300 T390 E Q H V R Y E T T G P A L C T
Chimpanzee Pan troglodytes XP_001142144 668 70462 T370 E Q R V R Y E T T G P A L C T
Rhesus Macaque Macaca mulatta XP_001096837 635 68033 G342 H E K V A C S G G A P G A G G
Dog Lupus familis XP_545614 589 64543 I305 C S R E H S H I H Y E T T G P
Cat Felis silvestris
Mouse Mus musculus Q61091 685 73197 T388 E Q H V R Y E T T G P A L C T
Rat Rattus norvegicus Q498S8 684 72990 T387 E Q H V R Y E T T G P A L C T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q9IA06 523 59263 I238 F R Y P E R P I I F L S G C Y
Frog Xenopus laevis O93274 581 65360 V297 L I A G H E K V A C S R G E L
Zebra Danio Brachydanio rerio NP_570993 579 65231 G295 Y I V R L I A G H E K V A C N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VVX3 694 75433 S389 G L L L R E S S T G P H S C T
Honey Bee Apis mellifera XP_397259 711 74000 A410 G S A L K S R A Q G P E A C V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188449 555 62346 S271 E R P I I F L S A C Y F M V A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.9 86.3 59.7 N.A. 95.5 95.8 N.A. N.A. 40.6 70.6 71 N.A. 50.4 47.5 N.A. 53.4
Protein Similarity: 100 96.1 88.1 67.4 N.A. 95.9 96.2 N.A. N.A. 52.5 75.6 76.5 N.A. 60.8 58.2 N.A. 63.2
P-Site Identity: 100 93.3 13.3 0 N.A. 100 100 N.A. N.A. 6.6 0 6.6 N.A. 40 20 N.A. 6.6
P-Site Similarity: 100 93.3 20 0 N.A. 100 100 N.A. N.A. 26.6 6.6 6.6 N.A. 53.3 33.3 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 17 0 9 0 9 9 17 9 0 34 25 0 9 % A
% Cys: 9 0 0 0 0 9 0 0 0 17 0 0 0 67 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 42 9 0 9 9 17 34 0 0 9 9 9 0 9 0 % E
% Phe: 9 0 0 0 0 9 0 0 0 9 0 9 0 0 0 % F
% Gly: 17 0 0 9 0 0 0 17 9 50 0 9 17 17 9 % G
% His: 9 0 25 0 17 0 9 0 17 0 0 9 0 0 0 % H
% Ile: 0 17 0 9 9 9 0 17 9 0 0 0 0 0 0 % I
% Lys: 0 0 9 0 9 0 9 0 0 0 9 0 0 0 0 % K
% Leu: 9 9 9 17 9 0 9 0 0 0 9 0 34 0 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % N
% Pro: 0 0 9 9 0 0 9 0 0 0 59 0 0 0 9 % P
% Gln: 0 34 0 0 0 0 0 0 9 0 0 0 0 0 0 % Q
% Arg: 0 17 17 9 42 9 9 0 0 0 0 9 0 0 0 % R
% Ser: 0 17 0 0 0 17 17 17 0 0 9 9 9 0 0 % S
% Thr: 0 0 0 0 0 0 0 34 42 0 0 9 9 0 42 % T
% Val: 0 0 9 42 0 0 0 9 0 0 0 9 0 9 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 9 0 0 34 0 0 0 9 9 0 0 0 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _