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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FZD8
All Species:
22.12
Human Site:
Y125
Identified Species:
44.24
UniProt:
Q9H461
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H461
NP_114072.1
694
73300
Y125
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
Chimpanzee
Pan troglodytes
XP_001142144
668
70462
P148
P
S
P
P
R
R
L
P
P
P
P
P
G
E
Q
Rhesus Macaque
Macaca mulatta
XP_001096837
635
68033
Y125
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
Dog
Lupus familis
XP_545614
589
64543
K113
R
S
V
C
E
R
A
K
A
G
C
S
P
L
M
Cat
Felis silvestris
Mouse
Mus musculus
Q61091
685
73197
Y125
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
Rat
Rattus norvegicus
Q498S8
684
72990
Y125
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q9IA06
523
59263
L46
E
V
H
Q
F
Y
P
L
V
K
V
Q
C
S
L
Frog
Xenopus laevis
O93274
581
65360
E105
P
P
C
R
S
V
C
E
R
A
R
A
G
C
A
Zebra Danio
Brachydanio rerio
NP_570993
579
65231
R103
K
K
P
L
P
P
C
R
S
V
C
E
R
A
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVX3
694
75433
Y154
C
A
P
I
M
Q
Q
Y
S
F
E
W
P
E
R
Honey Bee
Apis mellifera
XP_397259
711
74000
Y188
C
A
P
L
M
Q
Q
Y
G
F
S
W
P
E
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001188449
555
62346
V79
V
H
Q
F
Y
P
L
V
E
I
Q
C
S
P
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.9
86.3
59.7
N.A.
95.5
95.8
N.A.
N.A.
40.6
70.6
71
N.A.
50.4
47.5
N.A.
53.4
Protein Similarity:
100
96.1
88.1
67.4
N.A.
95.9
96.2
N.A.
N.A.
52.5
75.6
76.5
N.A.
60.8
58.2
N.A.
63.2
P-Site Identity:
100
13.3
100
13.3
N.A.
100
100
N.A.
N.A.
0
0
13.3
N.A.
66.6
80
N.A.
0
P-Site Similarity:
100
33.3
100
20
N.A.
100
100
N.A.
N.A.
0
0
20
N.A.
86.6
100
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
50
0
0
0
0
9
0
9
9
34
9
0
9
9
% A
% Cys:
50
0
9
9
0
0
17
0
0
0
17
9
9
9
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
34
9
% D
% Glu:
9
0
0
0
9
0
0
9
9
0
9
9
0
25
0
% E
% Phe:
0
0
0
9
9
0
0
0
0
50
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
42
9
0
0
17
0
0
% G
% His:
0
9
9
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
9
0
0
0
0
0
9
0
0
0
0
0
% I
% Lys:
9
9
0
0
0
0
0
9
0
9
0
0
0
0
9
% K
% Leu:
0
0
0
50
0
0
17
9
0
0
0
0
0
9
9
% L
% Met:
0
0
0
0
50
0
0
0
0
0
0
0
0
0
9
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
17
9
67
9
9
17
9
9
9
9
9
9
59
9
0
% P
% Gln:
0
0
9
9
0
17
50
0
0
0
9
9
0
0
9
% Q
% Arg:
9
0
0
9
9
50
0
9
9
0
9
0
9
0
50
% R
% Ser:
0
17
0
0
9
0
0
0
17
0
9
9
9
9
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
9
9
9
0
0
9
0
9
9
9
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
50
0
0
0
% W
% Tyr:
0
0
0
0
9
9
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _