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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WNK1 All Species: 16.36
Human Site: S1550 Identified Species: 45
UniProt: Q9H4A3 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H4A3 NP_061852.2 2382 250756 S1550 S L S A P S S S S S P G A G V
Chimpanzee Pan troglodytes XP_508919 2382 250683 S1550 S L S A P S S S S S P G A G V
Rhesus Macaque Macaca mulatta XP_001095845 2384 250725 S1550 S L S A P S S S S S P G A G V
Dog Lupus familis XP_853960 2389 250985 S1553 S L S A S S S S P G A G L S S
Cat Felis silvestris
Mouse Mus musculus P83741 2377 251030 S1545 F C A P S S S S S S G T A V S
Rat Rattus norvegicus Q9JIH7 2126 225198 L1325 A I A S T P V L P Q P A V P T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508024 2425 260713 T1614 V S E P P S L T G S Q L P S P
Chicken Gallus gallus XP_001235131 2380 248875 S1555 L P I S A P L S S S V A T S L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002666892 1684 182757 V883 I S N I G D R V A E C Q L E T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 96.8 89.9 N.A. 85.5 77.6 N.A. 31.4 69.4 N.A. 37.3 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.3 97.6 92.7 N.A. 89.4 81.2 N.A. 44.9 77.8 N.A. 47.5 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 53.3 N.A. 40 6.6 N.A. 20 20 N.A. 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 53.3 N.A. 46.6 33.3 N.A. 26.6 33.3 N.A. 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 23 45 12 0 0 0 12 0 12 23 45 0 0 % A
% Cys: 0 12 0 0 0 0 0 0 0 0 12 0 0 0 0 % C
% Asp: 0 0 0 0 0 12 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 12 0 0 0 0 0 0 12 0 0 0 12 0 % E
% Phe: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 12 0 0 0 12 12 12 45 0 34 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 12 12 12 12 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 12 45 0 0 0 0 23 12 0 0 0 12 23 0 12 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 12 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 12 0 23 45 23 0 0 23 0 45 0 12 12 12 % P
% Gln: 0 0 0 0 0 0 0 0 0 12 12 12 0 0 0 % Q
% Arg: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 % R
% Ser: 45 23 45 23 23 67 56 67 56 67 0 0 0 34 23 % S
% Thr: 0 0 0 0 12 0 0 12 0 0 0 12 12 0 23 % T
% Val: 12 0 0 0 0 0 12 12 0 0 12 0 12 12 34 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _