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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WNK1 All Species: 11.52
Human Site: S1888 Identified Species: 31.67
UniProt: Q9H4A3 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H4A3 NP_061852.2 2382 250756 S1888 K S V H F E S S T S E S S V L
Chimpanzee Pan troglodytes XP_508919 2382 250683 S1888 K S V H F E S S T S E S S V L
Rhesus Macaque Macaca mulatta XP_001095845 2384 250725 E1888 D A K S V H F E S S T S E S S
Dog Lupus familis XP_853960 2389 250985 S1895 K S V H F E S S T S E S S V L
Cat Felis silvestris
Mouse Mus musculus P83741 2377 251030 S1882 T K S V H F E S S T S E S S V
Rat Rattus norvegicus Q9JIH7 2126 225198 G1661 P N G I T V S G I S L D V P D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508024 2425 260713 D1951 V S N D S A D D C L K K M S S
Chicken Gallus gallus XP_001235131 2380 248875 S1897 F E T T S S D S S P L S G S S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002666892 1684 182757 L1219 S G V T P S S L S L N S S G N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 96.8 89.9 N.A. 85.5 77.6 N.A. 31.4 69.4 N.A. 37.3 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.3 97.6 92.7 N.A. 89.4 81.2 N.A. 44.9 77.8 N.A. 47.5 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 13.3 100 N.A. 13.3 13.3 N.A. 6.6 13.3 N.A. 26.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 26.6 100 N.A. 33.3 20 N.A. 13.3 20 N.A. 33.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 12 0 0 0 12 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % C
% Asp: 12 0 0 12 0 0 23 12 0 0 0 12 0 0 12 % D
% Glu: 0 12 0 0 0 34 12 12 0 0 34 12 12 0 0 % E
% Phe: 12 0 0 0 34 12 12 0 0 0 0 0 0 0 0 % F
% Gly: 0 12 12 0 0 0 0 12 0 0 0 0 12 12 0 % G
% His: 0 0 0 34 12 12 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 12 0 0 0 0 12 0 0 0 0 0 0 % I
% Lys: 34 12 12 0 0 0 0 0 0 0 12 12 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 12 0 23 23 0 0 0 34 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % M
% Asn: 0 12 12 0 0 0 0 0 0 0 12 0 0 0 12 % N
% Pro: 12 0 0 0 12 0 0 0 0 12 0 0 0 12 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 12 45 12 12 23 23 56 56 45 56 12 67 56 45 34 % S
% Thr: 12 0 12 23 12 0 0 0 34 12 12 0 0 0 0 % T
% Val: 12 0 45 12 12 12 0 0 0 0 0 0 12 34 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _