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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEF6
All Species:
16.36
Human Site:
S581
Identified Species:
36
UniProt:
Q9H4E7
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H4E7
NP_071330.3
631
73910
S581
L
L
A
H
R
D
S
S
L
K
R
L
T
R
W
Chimpanzee
Pan troglodytes
XP_518424
631
73898
S581
L
L
A
R
R
D
S
S
L
K
R
L
T
R
W
Rhesus Macaque
Macaca mulatta
XP_001116665
631
73997
S581
L
L
A
R
R
D
S
S
L
K
R
L
T
R
W
Dog
Lupus familis
XP_542503
666
77164
Q621
S
W
K
D
K
V
A
Q
H
E
G
L
I
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8C2K1
630
73435
S581
P
L
A
R
R
D
S
S
L
K
R
L
T
R
W
Rat
Rattus norvegicus
XP_228031
630
73547
S581
P
L
A
R
R
D
S
S
L
K
R
L
T
R
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510112
591
69266
I545
V
A
Q
H
E
G
L
I
R
L
I
E
P
G
S
Chicken
Gallus gallus
Q5F4B2
586
68393
H540
S
W
K
D
K
V
A
H
H
E
G
L
I
R
L
Frog
Xenopus laevis
Q6PA69
596
70153
P547
R
L
M
H
P
I
S
P
G
E
K
R
I
V
S
Zebra Danio
Brachydanio rerio
Q7SYB5
612
72072
P567
S
F
S
S
F
R
I
P
S
Q
K
D
P
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_790206
454
53839
A409
E
I
D
A
L
K
A
A
R
D
D
V
A
R
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.8
41.4
N.A.
92.5
92.8
N.A.
44.2
44
60.3
67
N.A.
N.A.
N.A.
N.A.
26.9
Protein Similarity:
100
99.6
99.2
60.2
N.A.
95.4
95.8
N.A.
63.8
64.8
77.3
80.5
N.A.
N.A.
N.A.
N.A.
45
P-Site Identity:
100
93.3
93.3
13.3
N.A.
86.6
86.6
N.A.
6.6
13.3
20
0
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
93.3
93.3
33.3
N.A.
86.6
86.6
N.A.
13.3
33.3
33.3
20
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
46
10
0
0
28
10
0
0
0
0
10
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
19
0
46
0
0
0
10
10
10
0
0
0
% D
% Glu:
10
0
0
0
10
0
0
0
0
28
0
10
0
0
0
% E
% Phe:
0
10
0
0
10
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
0
0
10
0
19
0
0
10
0
% G
% His:
0
0
0
28
0
0
0
10
19
0
0
0
0
0
0
% H
% Ile:
0
10
0
0
0
10
10
10
0
0
10
0
28
0
0
% I
% Lys:
0
0
19
0
19
10
0
0
0
46
19
0
0
0
10
% K
% Leu:
28
55
0
0
10
0
10
0
46
10
0
64
0
0
28
% L
% Met:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
19
0
0
0
10
0
0
19
0
0
0
0
19
0
0
% P
% Gln:
0
0
10
0
0
0
0
10
0
10
0
0
0
0
0
% Q
% Arg:
10
0
0
37
46
10
0
0
19
0
46
10
0
73
0
% R
% Ser:
28
0
10
10
0
0
55
46
10
0
0
0
0
0
19
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
46
0
0
% T
% Val:
10
0
0
0
0
19
0
0
0
0
0
10
0
10
0
% V
% Trp:
0
19
0
0
0
0
0
0
0
0
0
0
0
0
46
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _