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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ALG2 All Species: 23.94
Human Site: S291 Identified Species: 35.11
UniProt: Q9H553 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H553 NP_149078.1 416 47092 S291 L K K M V Q Q S D L G Q Y V T
Chimpanzee Pan troglodytes XP_528363 416 47103 S291 L K K M V Q Q S D L G Q Y V T
Rhesus Macaque Macaca mulatta XP_001112564 416 47090 S291 L K Q M V Q Q S D L G Q Y V T
Dog Lupus familis XP_532010 416 46742 S291 L K K M V Q Q S D L A Q C V T
Cat Felis silvestris
Mouse Mus musculus Q9DBE8 415 47386 S291 L K K M V Q E S D L E R H V T
Rat Rattus norvegicus NP_001094180 415 47300 S291 L K K I V Q E S D L E R H V T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q08B22 486 54690 S358 S E L K K L S S E L G I P V E
Zebra Danio Brachydanio rerio NP_001098406 402 45631 L277 L R S L V T S L G L E D H V T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_647772 424 48580 L288 L E H L T E E L K L Q D H V V
Honey Bee Apis mellifera XP_624358 407 46636 L277 L I G L V D E L H V T E K V I
Nematode Worm Caenorhab. elegans NP_495010 400 45591 E276 V E H M K K L E L P A D Q I V
Sea Urchin Strong. purpuratus XP_794663 401 45536 L275 L V Q R A D E L K L T D H V T
Poplar Tree Populus trichocarpa XP_002317454 413 46341 E284 L K H L A A R E G V S S R I S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_178001 403 45009 E273 L R S L A E K E G V S D R V N
Baker's Yeast Sacchar. cerevisiae P43636 503 58029 K301 V S D L E S F K T N N S K I I
Red Bread Mold Neurospora crassa Q8X0H8 471 51906 T311 T V V S A L N T S P D V E V L
Conservation
Percent
Protein Identity: 100 99.7 97.1 90.3 N.A. 80.7 81.4 N.A. N.A. N.A. 21.8 65.1 N.A. 50.4 50.2 45.4 59.8
Protein Similarity: 100 99.7 99 95.1 N.A. 90.3 90.3 N.A. N.A. N.A. 39 78.6 N.A. 67.2 67.5 64.4 75.2
P-Site Identity: 100 100 93.3 86.6 N.A. 73.3 66.6 N.A. N.A. N.A. 26.6 33.3 N.A. 20 20 6.6 26.6
P-Site Similarity: 100 100 100 86.6 N.A. 93.3 93.3 N.A. N.A. N.A. 40 53.3 N.A. 53.3 46.6 33.3 46.6
Percent
Protein Identity: 44.7 N.A. N.A. 47.6 34.3 37.7
Protein Similarity: 62.7 N.A. N.A. 64.4 53 53.9
P-Site Identity: 13.3 N.A. N.A. 13.3 0 6.6
P-Site Similarity: 46.6 N.A. N.A. 46.6 20 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 25 7 0 0 0 0 13 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 0 0 7 0 0 13 0 0 38 0 7 32 0 0 0 % D
% Glu: 0 19 0 0 7 13 32 19 7 0 19 7 7 0 7 % E
% Phe: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 7 0 0 0 0 0 19 0 25 0 0 0 0 % G
% His: 0 0 19 0 0 0 0 0 7 0 0 0 32 0 0 % H
% Ile: 0 7 0 7 0 0 0 0 0 0 0 7 0 19 13 % I
% Lys: 0 44 32 7 13 7 7 7 13 0 0 0 13 0 0 % K
% Leu: 75 0 7 38 0 13 7 25 7 63 0 0 0 0 7 % L
% Met: 0 0 0 38 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 7 0 0 7 7 0 0 0 7 % N
% Pro: 0 0 0 0 0 0 0 0 0 13 0 0 7 0 0 % P
% Gln: 0 0 13 0 0 38 25 0 0 0 7 25 7 0 0 % Q
% Arg: 0 13 0 7 0 0 7 0 0 0 0 13 13 0 0 % R
% Ser: 7 7 13 7 0 7 13 44 7 0 13 13 0 0 7 % S
% Thr: 7 0 0 0 7 7 0 7 7 0 13 0 0 0 50 % T
% Val: 13 13 7 0 50 0 0 0 0 19 0 7 0 82 13 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 19 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _