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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ALG2 All Species: 25.76
Human Site: S381 Identified Species: 37.78
UniProt: Q9H553 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H553 NP_149078.1 416 47092 S381 E K F I R E P S L K A T M G L
Chimpanzee Pan troglodytes XP_528363 416 47103 S381 E K F I R E P S L K A T M G L
Rhesus Macaque Macaca mulatta XP_001112564 416 47090 S381 E K F I R E P S L K A T M G L
Dog Lupus familis XP_532010 416 46742 S381 E K F I H E P S L K A T M G L
Cat Felis silvestris
Mouse Mus musculus Q9DBE8 415 47386 S381 E K F I H K P S L K A T M G L
Rat Rattus norvegicus NP_001094180 415 47300 S381 E K F I H K P S L K A T M G L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q08B22 486 54690 S448 A A M D H I L S L T P E Q R L
Zebra Danio Brachydanio rerio NP_001098406 402 45631 T367 Q N F V L D P T L K Q R M G Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_647772 424 48580 Q378 L Q L F R D E Q L R V K M G D
Honey Bee Apis mellifera XP_624358 407 46636 E367 A Y L I K N P E Y I Q E F G N
Nematode Worm Caenorhab. elegans NP_495010 400 45591 E366 I D L M K D E E M Y R R M S E
Sea Urchin Strong. purpuratus XP_794663 401 45536 D365 E R F V R E P D L K N R L G K
Poplar Tree Populus trichocarpa XP_002317454 413 46341 Q374 A K L I Q D P Q M A S R M G G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_178001 403 45009 E363 A R F I E N P E L A N R M G A
Baker's Yeast Sacchar. cerevisiae P43636 503 58029 I391 P I Q W A T A I D E S R K I L
Red Bread Mold Neurospora crassa Q8X0H8 471 51906 M401 M D K V L N G M G E E E L K R
Conservation
Percent
Protein Identity: 100 99.7 97.1 90.3 N.A. 80.7 81.4 N.A. N.A. N.A. 21.8 65.1 N.A. 50.4 50.2 45.4 59.8
Protein Similarity: 100 99.7 99 95.1 N.A. 90.3 90.3 N.A. N.A. N.A. 39 78.6 N.A. 67.2 67.5 64.4 75.2
P-Site Identity: 100 100 100 93.3 N.A. 86.6 86.6 N.A. N.A. N.A. 20 40 N.A. 26.6 20 6.6 53.3
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. N.A. N.A. 20 66.6 N.A. 46.6 26.6 33.3 73.3
Percent
Protein Identity: 44.7 N.A. N.A. 47.6 34.3 37.7
Protein Similarity: 62.7 N.A. N.A. 64.4 53 53.9
P-Site Identity: 33.3 N.A. N.A. 40 6.6 0
P-Site Similarity: 60 N.A. N.A. 46.6 20 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 25 7 0 0 7 0 7 0 0 13 38 0 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 13 0 7 0 25 0 7 7 0 0 0 0 0 7 % D
% Glu: 44 0 0 0 7 32 13 19 0 13 7 19 0 0 7 % E
% Phe: 0 0 57 7 0 0 0 0 0 0 0 0 7 0 0 % F
% Gly: 0 0 0 0 0 0 7 0 7 0 0 0 0 75 7 % G
% His: 0 0 0 0 25 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 7 0 57 0 7 0 7 0 7 0 0 0 7 0 % I
% Lys: 0 44 7 0 13 13 0 0 0 50 0 7 7 7 7 % K
% Leu: 7 0 25 0 13 0 7 0 69 0 0 0 13 0 50 % L
% Met: 7 0 7 7 0 0 0 7 13 0 0 0 69 0 0 % M
% Asn: 0 7 0 0 0 19 0 0 0 0 13 0 0 0 7 % N
% Pro: 7 0 0 0 0 0 69 0 0 0 7 0 0 0 0 % P
% Gln: 7 7 7 0 7 0 0 13 0 0 13 0 7 0 7 % Q
% Arg: 0 13 0 0 32 0 0 0 0 7 7 38 0 7 7 % R
% Ser: 0 0 0 0 0 0 0 44 0 0 13 0 0 7 0 % S
% Thr: 0 0 0 0 0 7 0 7 0 7 0 38 0 0 0 % T
% Val: 0 0 0 19 0 0 0 0 0 0 7 0 0 0 0 % V
% Trp: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 0 0 0 0 7 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _