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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DHX35 All Species: 23.03
Human Site: S46 Identified Species: 36.19
UniProt: Q9H5Z1 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H5Z1 NP_068750.2 703 78910 S46 Y N P Y A A L S I E Q Q R Q K
Chimpanzee Pan troglodytes Q7YR39 1044 119631 S117 T V S R A G S S L Q K K R K K
Rhesus Macaque Macaca mulatta XP_001088680 703 78826 S46 Y N P Y A A L S I E Q Q R Q K
Dog Lupus familis XP_542996 769 85800 S46 Y N P Y A A L S I E Q Q R Q K
Cat Felis silvestris
Mouse Mus musculus A2A4P0 1244 142553 K109 K D P V V K P K T E K E K L R
Rat Rattus norvegicus Q5XI69 779 88496 K40 R I A D R E E K G C T S Q E G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512863 703 79017 S46 Y N P H A A L S V E Q Q R Q K
Chicken Gallus gallus XP_417352 703 78661 S46 Y N P Y A S L S I E Q Q R Q K
Frog Xenopus laevis Q5XH12 748 85094 F54 G L P Y S S R F Y K L L K E R
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_396598 671 75928 Y39 Q R L P T F K Y K S H I I Y L
Nematode Worm Caenorhab. elegans Q9BKQ8 732 82525 N69 N N P Y A S L N I Q Q Q R I R
Sea Urchin Strong. purpuratus O17438 455 51461
Poplar Tree Populus trichocarpa XP_002305762 702 78145 G41 A S S S S R F G Y A S I G S Q
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38953 1168 134139 N457 D S I P K D L N R P W E D P M
Baker's Yeast Sacchar. cerevisiae P24384 1145 129992 S109 S I L N K S K S I T E F Q E Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 29.6 98.2 88.1 N.A. 26.5 34.4 N.A. 90.9 90 27.8 N.A. N.A. N.A. 53.6 51.3 32.4
Protein Similarity: 100 44.1 99 89.8 N.A. 39 53.4 N.A. 96.7 95.8 49 N.A. N.A. N.A. 72.5 70.9 46.6
P-Site Identity: 100 26.6 100 100 N.A. 13.3 0 N.A. 86.6 93.3 13.3 N.A. N.A. N.A. 0 60 0
P-Site Similarity: 100 60 100 100 N.A. 46.6 13.3 N.A. 100 100 53.3 N.A. N.A. N.A. 0 86.6 0
Percent
Protein Identity: 49 N.A. N.A. 25.8 28.2 N.A.
Protein Similarity: 68.2 N.A. N.A. 39.9 42 N.A.
P-Site Identity: 0 N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: 20 N.A. N.A. 26.6 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 7 0 47 27 0 0 0 7 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % C
% Asp: 7 7 0 7 0 7 0 0 0 0 0 0 7 0 0 % D
% Glu: 0 0 0 0 0 7 7 0 0 40 7 14 0 20 0 % E
% Phe: 0 0 0 0 0 7 7 7 0 0 0 7 0 0 0 % F
% Gly: 7 0 0 0 0 7 0 7 7 0 0 0 7 0 7 % G
% His: 0 0 0 7 0 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 0 14 7 0 0 0 0 0 40 0 0 14 7 7 0 % I
% Lys: 7 0 0 0 14 7 14 14 7 7 14 7 14 7 40 % K
% Leu: 0 7 14 0 0 0 47 0 7 0 7 7 0 7 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % M
% Asn: 7 40 0 7 0 0 0 14 0 0 0 0 0 0 0 % N
% Pro: 0 0 54 14 0 0 7 0 0 7 0 0 0 7 0 % P
% Gln: 7 0 0 0 0 0 0 0 0 14 40 40 14 34 14 % Q
% Arg: 7 7 0 7 7 7 7 0 7 0 0 0 47 0 20 % R
% Ser: 7 14 14 7 14 27 7 47 0 7 7 7 0 7 0 % S
% Thr: 7 0 0 0 7 0 0 0 7 7 7 0 0 0 0 % T
% Val: 0 7 0 7 7 0 0 0 7 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % W
% Tyr: 34 0 0 40 0 0 0 7 14 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _