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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DHX35 All Species: 20.61
Human Site: Y645 Identified Species: 32.38
UniProt: Q9H5Z1 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H5Z1 NP_068750.2 703 78910 Y645 I H P A S V L Y A E K P P R W
Chimpanzee Pan troglodytes Q7YR39 1044 119631 L979 F I H P N S S L F E Q Q P R W
Rhesus Macaque Macaca mulatta XP_001088680 703 78826 Y645 I H P A S V L Y A E K P P R W
Dog Lupus familis XP_542996 769 85800 Y645 I H P A S V L Y A E K P P R W
Cat Felis silvestris
Mouse Mus musculus A2A4P0 1244 142553 L1165 Y I H P S S A L F N R Q P E W
Rat Rattus norvegicus Q5XI69 779 88496 E660 H P S S A L H E Q E T K L E W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512863 703 79017 Y645 I H P T S V L Y A E K P P R W
Chicken Gallus gallus XP_417352 703 78661 Y645 I H P T S V L Y A E K P P R W
Frog Xenopus laevis Q5XH12 748 85094 F657 Q L H P D S G F C N S A K V P
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_396598 671 75928 H617 G N K D L Y I H P N S C L Y T
Nematode Worm Caenorhab. elegans Q9BKQ8 732 82525 M667 M Y K G S S I M F K K D Y P K
Sea Urchin Strong. purpuratus O17438 455 51461 A401 T L L N V Y H A F K Q N N E D
Poplar Tree Populus trichocarpa XP_002305762 702 78145 S648 Q E V Y I H P S S V L F R V N
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38953 1168 134139 F1092 I H P S S A L F Q R Q P D W V
Baker's Yeast Sacchar. cerevisiae P24384 1145 129992 Y1060 I H P S S S L Y G K E Y E Y V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 29.6 98.2 88.1 N.A. 26.5 34.4 N.A. 90.9 90 27.8 N.A. N.A. N.A. 53.6 51.3 32.4
Protein Similarity: 100 44.1 99 89.8 N.A. 39 53.4 N.A. 96.7 95.8 49 N.A. N.A. N.A. 72.5 70.9 46.6
P-Site Identity: 100 26.6 100 100 N.A. 20 13.3 N.A. 93.3 93.3 0 N.A. N.A. N.A. 0 13.3 0
P-Site Similarity: 100 40 100 100 N.A. 26.6 33.3 N.A. 93.3 93.3 6.6 N.A. N.A. N.A. 20 40 13.3
Percent
Protein Identity: 49 N.A. N.A. 25.8 28.2 N.A.
Protein Similarity: 68.2 N.A. N.A. 39.9 42 N.A.
P-Site Identity: 0 N.A. N.A. 40 40 N.A.
P-Site Similarity: 6.6 N.A. N.A. 60 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 20 7 7 7 7 34 0 0 7 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 7 0 0 7 0 0 0 % C
% Asp: 0 0 0 7 7 0 0 0 0 0 0 7 7 0 7 % D
% Glu: 0 7 0 0 0 0 0 7 0 47 7 0 7 20 0 % E
% Phe: 7 0 0 0 0 0 0 14 27 0 0 7 0 0 0 % F
% Gly: 7 0 0 7 0 0 7 0 7 0 0 0 0 0 0 % G
% His: 7 47 20 0 0 7 14 7 0 0 0 0 0 0 0 % H
% Ile: 47 14 0 0 7 0 14 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 14 0 0 0 0 0 0 20 40 7 7 0 7 % K
% Leu: 0 14 7 0 7 7 47 14 0 0 7 0 14 0 0 % L
% Met: 7 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % M
% Asn: 0 7 0 7 7 0 0 0 0 20 0 7 7 0 7 % N
% Pro: 0 7 47 20 0 0 7 0 7 0 0 40 47 7 7 % P
% Gln: 14 0 0 0 0 0 0 0 14 0 20 14 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 7 7 0 7 40 0 % R
% Ser: 0 0 7 20 60 34 7 7 7 0 14 0 0 0 0 % S
% Thr: 7 0 0 14 0 0 0 0 0 0 7 0 0 0 7 % T
% Val: 0 0 7 0 7 34 0 0 0 7 0 0 0 14 14 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 54 % W
% Tyr: 7 7 0 7 0 14 0 40 0 0 0 7 7 14 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _